MEGF10 association with schizophrenia

Biological Psychiatry
X ChenK S Kendler

Abstract

The 5q21-31 region has been implicated as harboring risk genes for schizophrenia in many linkage studies. In our previous report of stepwise fine mapping of this region, the MEGF10 gene was one of the genes showing consistent associations in our screening subsample. In this study, we carried out independent replication and expression studies of the MEGF10 gene. Association studies with 8 SNPs in the MEGF10 gene were performed in the Irish case-control study of schizophrenia (ICCSS) sample (652 case and 617 control subjects). The expression of MEGF10 was also compared between healthy control subjects and schizophrenia patients using postmortem brain cDNA libraries. In the ICCSS sample, associations with the disease were found in the same risk alleles and haplotypes as that observed in our fine-mapping studies. The major allele (A) of rs27388 was overrepresented in affected individuals (p = .0169), which remained significant after correction for multiple testing. In expression studies, MEGF10 had higher expression levels in the affected than the unaffected (p = .015). Schizophrenia patients with a 1/1 genotype at rs27388 had higher expressions than those patients with 1/2 and 2/2 genotypes (p = .0008). Evidence from both associat...Continue Reading

References

Oct 1, 1993·Archives of General Psychiatry·K S KendlerD Walsh
Mar 20, 1999·Genetic Analysis : Biomolecular Engineering·K J Livak
Sep 16, 1999·American Journal of Human Genetics·D Clayton, H Jones
May 29, 2000·American Journal of Human Genetics·E R MartinN L Kaplan
Oct 31, 2000·Genetic Epidemiology·N M LairdX Xu
Feb 13, 2001·Bioinformatics·J A BedellW Gish
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
May 25, 2002·Human Molecular Genetics·Kodavali V ChowdariVishwajit L Nimgaonkar
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Oct 15, 2003·Genetic Epidemiology·E R MartinE R Hauser
Jun 9, 2004·Genetic Epidemiology·Elizabeth R HauserMichael Boehnke
Jul 24, 2004·American Journal of Human Genetics·Benjamin M Neale, Pak C Sham
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 17, 2004·Molecular Psychiatry·T L PetryshenP Sklar
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
Aug 6, 2005·Schizophrenia Bulletin·Sarah TosatoDavid Collier
Sep 17, 2005·Schizophrenia Bulletin·Nigel M WilliamsMichael J Owen
Sep 21, 2005·Molecular Psychiatry·T L PetryshenP Sklar
Mar 16, 2006·European Journal of Human Genetics : EJHG·Stuart MacgregorPeter A Holmans
Apr 14, 2006·Current Opinion in Psychiatry·Nadine NortonMichael J Owen
May 25, 2006·European Journal of Human Genetics : EJHG·Brien Riley, Kenneth S Kendler
Oct 13, 2006·Human Molecular Genetics·Xiangning ChenKenneth S Kendler
Dec 21, 2006·Molecular Psychiatry·X ChenK S Kendler
Jan 6, 2007·PloS One·Yannick HamonGiovanna Chimini
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Caroline SchmitzHarald Hutter
Mar 10, 2007·Biological Psychiatry·Patrick F Sullivan

❮ Previous
Next ❯

Citations

Sep 2, 2009·PloS One·Xiangning ChenKenneth S Kendler
Jan 27, 2010·Neurochemical Research·Anna BoyajyanAndranik Chavushyan
Jul 10, 2020·The European Journal of Neuroscience·Celia RomanBarbara Di Benedetto
Jul 24, 2012·Molecular and Cellular Biochemistry·Kentaro Oh-hashiKazutoshi Kiuchi
Mar 7, 2021·Genes·Jirrine T T Hogenaar, Hans van Bokhoven
Apr 9, 2021·Frontiers in Medicine·Dragan PrimoracJohannes Brachmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here