Megistoquinones I and II, two quinoline alkaloids with antibacterial activity from the bark of Sarcomelicope megistophylla

Chemical & Pharmaceutical Bulletin
Nikolas FokialakisFrançois Tillequin

Abstract

Two alkaloids, megistoquinone I (1) and megistoquinone II (2), were isolated from the bark of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of MS and NMR data. Both belong to quinoline alkaloid series and should be considered as oxidation products of a furo[2,3-b]quinoline precursor. The two alkaloids showed antibacterial properties with minimum inhibitory concentration (MIC) ranging from 2.35 to 5.25 mg/ml for 1 and 0.73 to 1.23 mg/ml for 2.

References

Apr 11, 2000·Journal of Natural Products·M PapageorgiouT Sévenet

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Citations

May 3, 2006·Chemical & Pharmaceutical Bulletin·Annett MikolaschUlrike Lindequist
Mar 3, 2007·Chemical & Pharmaceutical Bulletin·Annett MikolaschUlrike Lindequist
Jun 4, 2008·Chemical & Pharmaceutical Bulletin·Annett MikolaschFrieder Schauer
Jan 1, 2012·International Journal of Medicinal Chemistry·Surendra N Pandeya, Neha Rajput
Nov 29, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Islam H El AzabMahmoud A Amin
Jun 2, 2015·Tetrahedron Letters·Christopher D McCuneDavid B Berkowitz
Sep 14, 2017·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Sep 30, 2015·Magnetic Resonance in Chemistry : MRC·Baris AnilCavit Kazaz
May 24, 2014·Archiv der Pharmazie·Reshma J NevagiKishor S Jain
Jul 9, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Elizabeth ChossonThierry Besson
Feb 4, 2011·Archiv der Pharmazie·Nilesh J Thumar, Manish P Patel

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