MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse

Journal of Cell Science
Rajeev KumarBernard de Massy

Abstract

The formation of programmed DNA double-strand breaks (DSBs) at the beginning of meiotic prophase marks the initiation of meiotic recombination. Meiotic DSB formation is catalyzed by SPO11 and their repair takes place on meiotic chromosome axes. The evolutionarily conserved MEI4 protein is required for meiotic DSB formation and is localized on chromosome axes. Here, we show that HORMAD1, one of the meiotic chromosome axis components, is required for MEI4 localization. Importantly, the quantitative correlation between the level of axis-associated MEI4 and DSB formation suggests that axis-associated MEI4 could be a limiting factor for DSB formation. We also show that MEI1, REC8 and RAD21L are important for proper MEI4 localization. These findings on MEI4 dynamics during meiotic prophase suggest that the association of MEI4 to chromosome axes is required for DSB formation, and that the loss of this association upon DSB repair could contribute to turning off meiotic DSB formation.

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Citations

Mar 25, 2017·Genome Research·Corinne GreyBernard de Massy
Jul 3, 2018·Cell Cycle·Agnieszka LukaszewiczMaria Jasin
Aug 31, 2018·PLoS Genetics·Corinne GreyBernard de Massy
Nov 28, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kei-Ichiro Ishiguro
Oct 4, 2019·Evolution; International Journal of Organic Evolution·Amy L Dapper, Bret A Payseur
May 29, 2020·Nature·Laurent AcquavivaScott Keeney
Feb 24, 2021·Nucleic Acids Research·Ihsan DereliAttila Tóth
Mar 19, 2021·Nature·Corentin Claeys BouuaertScott Keeney
Jan 26, 2018·Trends in Genetics : TIG·Kenneth Paigen, Petko M Petkov
Jun 11, 2021·Frontiers in Cell and Developmental Biology·Aditya N MhaskarWilly M Baarends
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Xiaoyi Wang, Melissa E Pepling
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Corinne Grey, Bernard de Massy
Aug 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Albert W HinmanAnne M Villeneuve

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