Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Seira MiyazakiYoshinori Watanabe

Abstract

In meiosis I, sister chromatids are captured by microtubules emanating from the same pole (mono-orientation), and centromeric cohesion is protected throughout anaphase. Shugoshin, which is localized to centromeres depending on the phosphorylation of histone H2A by Bub1 kinase, plays a central role in protecting meiotic cohesin Rec8 from separase cleavage. Another key meiotic kinetochore factor, meikin, may regulate cohesion protection, although the underlying molecular mechanisms remain elusive. Here, we show that fission yeast Moa1 (meikin), which associates stably with CENP-C during meiosis I, recruits Plo1 (polo-like kinase) to the kinetochores and phosphorylates Spc7 (KNL1) to accumulate Bub1. Consequently, in contrast to the transient kinetochore localization of mitotic Bub1, meiotic Bub1 persists at kinetochores until anaphase I. The meiotic Bub1 pool ensures robust Sgo1 (shugoshin) localization and cohesion protection at centromeres by cooperating with heterochromatin protein Swi6, which binds and stabilizes Sgo1. Furthermore, molecular genetic analyses show a hierarchical regulation of centromeric cohesion protection by meikin and shugoshin that is important for establishing meiosis-specific chromosome segregation. We p...Continue Reading

References

Jan 1, 1991·Methods in Enzymology·S MorenoP Nurse
Nov 14, 1997·Current Topics in Developmental Biology·D P Moore, T L Orr-Weaver
Oct 9, 2003·The EMBO Journal·Tomoya S KitajimaYoshinori Watanabe
Jan 31, 2004·Science·Adele L MarstonAngelika Amon
Dec 29, 2004·Current Biology : CB·Brian H LeeAngelika Amon
Mar 17, 2006·Nature·Tomoya S KitajimaYoshinori Watanabe
Dec 18, 2007·Nature Cell Biology·Jibak LeeYoshinori Watanabe
Jul 12, 2008·Annual Review of Cell and Developmental Biology·Itay OnnDouglas E Koshland
Aug 22, 2008·Nature·Yuya YamagishiYoshinori Watanabe
Nov 5, 2008·Nature Reviews. Genetics·Gloria A Brar, Angelika Amon
Dec 6, 2008·Genes & Development·Jan-Michael PetersJulia Schmitz
Apr 17, 2009·Nature·Takeshi SakunoYoshinori Watanabe
Nov 6, 2009·Annual Review of Genetics·Kim Nasmyth, Christian H Haering
Apr 13, 2010·Nature Cell Biology·Tadashi IshiguroYoshinori Watanabe
Oct 26, 2010·Genes & Development·Kikuë Tachibana-KonwalskiKim Nasmyth
Jan 29, 2011·EMBO Reports·Kei-ichiro IshiguroYoshinori Watanabe
May 17, 2012·Nature Reviews. Molecular Cell Biology·Yoshinori Watanabe
Jun 5, 2012·Nature Cell Biology·Yuya YamagishiYoshinori Watanabe
Sep 16, 2014·Trends in Cell Biology·Carlos Sacristan, Geert J P L Kops
Oct 11, 2014·Nature Reviews. Molecular Cell Biology·Nitobe London, Sue Biggins
Jan 17, 2015·Genes & Development·Eris Duro, Adèle L Marston
Jun 30, 2015·Cell Reports·Conrad von SchubertErich A Nigg
Oct 21, 2015·Current Biology : CB·Andrea Musacchio

❮ Previous
Next ❯

Citations

Dec 4, 2017·Cold Spring Harbor Symposia on Quantitative Biology·Seira MiyazakiYoshinori Watanabe
May 15, 2020·Essays in Biochemistry·Gisela Cairo, Soni Lacefield
Aug 8, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stefan Galander, Adèle L Marston
Dec 16, 2017·Human Reproduction Update·Jessica GreaneyHayden Homer
Sep 6, 2019·Wellcome Open Research·Stefan GalanderAdèle L Marston
Jan 15, 2021·International Journal of Molecular Sciences·Kim Kiat LimEe Sin Chen
Feb 25, 2021·Open Biology·Wilber EscorciaSusan L Forsburg
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Masamitsu SatoMika Toya
Apr 24, 2021·Genes & Development·Wei MaYoshinori Watanabe
Jul 17, 2021·Cell Cycle·James N Brandt, Yumi Kim
Aug 1, 2021·Developmental Cell·Nolan K MaierIain M Cheeseman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Yoshinori Watanabe, Tomoya S Kitajima
© 2022 Meta ULC. All rights reserved