Meiosis I is established through division-specific translational control of a cyclin.

Cell
Thomas M Carlile, Angelika Amon

Abstract

In budding yeast, key meiotic events such as DNA replication, recombination, and the meiotic divisions are controlled by Clb cyclin-dependent kinases (Clb-CDKs). Using a novel synchronization procedure, we have characterized the activity of these Clb-CDKs and observed a surprising diversity in their regulation during the meiotic divisions. Clb1-CDK activity is restricted to meiosis I, and Clb3-CDK activity to meiosis II, through 5'UTR-mediated translational control of its transcript. The analysis of cells inappropriately producing Clb3-CDKs during meiosis I furthermore defines Clb3 as an inhibitor of the meiosis I chromosome segregation program. Our results demonstrate an essential role for Clb-CDK regulation in establishing the meiotic chromosome segregation pattern.

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Citations

Nov 5, 2008·Nature Reviews. Genetics·Gloria A Brar, Angelika Amon
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Michelle A AttnerAngelika Amon
Dec 17, 2008·Molecular Biology of the Cell·Gloria A BrarAngelika Amon
Sep 5, 2008·Molecular Biology of the Cell·Hsiao-Chi LoNancy M Hollingsworth
Dec 2, 2010·Molecular Biology of the Cell·Grace S TanKatrina F Cooper
Jun 22, 2012·Molecular Biology of the Cell·Michelle A Attner, Angelika Amon
Nov 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Iva Kronja, Terry L Orr-Weaver
Oct 4, 2008·Genes & Development·Anuradha Sourirajan, Michael Lichten
Oct 4, 2008·Genes & Development·Nancy M Hollingsworth
Dec 24, 2011·Science·Gloria A BrarJonathan S Weissman
Dec 22, 2010·Molecular and Cellular Biology·Yi-Ju LaiTing-Fang Wang
Dec 5, 2012·Molecular and Cellular Biology·Elizabeth WhinstonEdward Winter
Nov 23, 2011·Molecular and Cellular Biology·Hsiao-Chi LoNancy M Hollingsworth
Mar 7, 2012·Microbiology and Molecular Biology Reviews : MMBR·Edward Winter
Feb 15, 2011·Cell Division·Woan-Yuh Tarn, Ming-Chih Lai
Jun 12, 2012·PLoS Genetics·Sudeep D AgarwalaGerald R Fink
Mar 26, 2009·Regenerative Medicine·Ornella ParoliniDörthe Schmidt
Dec 21, 2012·ELife·Soni Lacefield
Oct 12, 2013·Genes & Development·Seoyoung KimDean S Dawson
Apr 7, 2012·Cellular and Molecular Life Sciences : CMLS·Gary William KerrPrakash Arumugam
Jun 22, 2011·The Journal of Cell Biology·Farid Bizzari, Adele L Marston

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