Meiosis Leads to Pervasive Copy-Number Variation and Distorted Inheritance of Accessory Chromosomes of the Wheat Pathogen Zymoseptoria tritici

Genome Biology and Evolution
Simone FouchéDaniel Croll

Abstract

Meiosis is one of the most conserved molecular processes in eukaryotes. The fidelity of pairing and segregation of homologous chromosomes has a major impact on the proper transmission of genetic information. Aberrant chromosomal transmission can have major phenotypic consequences, yet the mechanisms are poorly understood. Fungi are excellent models to investigate processes of chromosomal transmission, because many species have highly polymorphic genomes that include accessory chromosomes. Inheritance of accessory chromosomes is often unstable and chromosomal losses have little impact on fitness. We analyzed chromosomal inheritance in 477 progeny coming from two crosses of the fungal wheat pathogen Zymoseptoria tritici. For this, we developed a high-throughput screening method based on restriction site-associated DNA sequencing that generated dense coverage of genetic markers along each chromosome. We identified rare instances of chromosomal duplications (disomy) in core chromosomes. Accessory chromosomes showed high overall frequencies of disomy. Chromosomal rearrangements were found exclusively on accessory chromosomes and were more frequent than disomy. Accessory chromosomes present in only one of the parents in an analyzed c...Continue Reading

References

Jan 1, 1976·Annual Review of Genetics·B S BakerL Sandler
Oct 23, 1997·Genes & Development·G S Roeder
Jul 11, 2000·Nature Genetics·T R HughesM J Marton
Apr 3, 2001·Nature Reviews. Genetics·T Hassold, P Hunt
Feb 5, 2004·Genome Biology·Stefan KurtzSteven L Salzberg
Jul 22, 2006·Science·Anna SelmeckiJudith Berman
Mar 28, 2008·Molecular Microbiology·Anna SelmeckiJudith Berman
Jun 19, 2008·Genetics·Eduardo M TorresAngelika Amon
Oct 15, 2008·PloS One·Nathan A BairdEric A Johnson
Jan 21, 2010·Genes, Chromosomes & Cancer·Judit PampalonaLaura Tusell
Jan 30, 2010·Bioinformatics·Aaron R Quinlan, Ira M Hall
May 25, 2010·Eukaryotic Cell·Anna SelmeckiJudith Berman
Jul 27, 2010·Current Opinion in Cell Biology·Norman PavelkaRong Li
Dec 25, 2010·Methods in Molecular Biology·Jianbo ZhangThomas Peterson
Nov 9, 2011·Methods in Molecular Biology·Paul D EtterWilliam A Cresko
Nov 22, 2011·Current Biology : CB·Stefano F F TorrianiDaniel Croll
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
May 10, 2012·PLoS Pathogens·Daniel Croll, Bruce A McDonald
Aug 29, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Guangbo ChenRong Li
Jan 1, 2012·Scientifica·Tomás Naranjo
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Jun 8, 2014·Human Molecular Genetics·Louise Harewood, Peter Fraser
Nov 2, 2014·G3 : Genes - Genomes - Genetics·Mark H LendenmannBruce A McDonald
May 17, 2015·Fungal Genetics and Biology : FG & B·Mark H LendenmannBruce A McDonald
Oct 10, 2015·Current Opinion in Genetics & Development·Suomeng DongSophien Kamoun
Nov 1, 2016·MBio·Clémence PlissonneauDaniel Croll

❮ Previous
Next ❯

Citations

Dec 18, 2018·Molecular Plant Pathology·Lamprinos FrantzeskakisRalph Panstruga
Apr 23, 2019·PLoS Genetics·Mareike MöllerEva H Stukenbrock
Jul 22, 2020·Phytopathology·He YangLi-Jun Ma
Dec 14, 2018·ELife·Michael HabigEva Holtgrewe Stukenbrock
Oct 9, 2021·Nature Communications·Michael HabigEva H Stukenbrock

❮ Previous
Next ❯

Datasets Mentioned

BETA
SRS383146
SRS383147
SRS383142
SRS383143
PRJNA256988
PRJNA256991

Methods Mentioned

BETA
Restriction Site-Associated DNA Sequencing
genotyping
restriction

Software Mentioned

coverageBed
NUCmer
BEDtools
bowtie
RADseq
FASTX
Freebayes
MUMmer
EMBOSS
intersectBed

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.