PMID: 60206Aug 17, 1976Paper

Meiosis of trisomy 21 in the human pachytene oocyte. Behaviour of the supernumerary chromosome, identification of chromomere sequence and numerous sub-bands

Chromosoma
J M LucianiA Stahl

Abstract

Association modalities of the three 21 chromosomes were studied during pachytene in three trisomy 21 fetuses whose chromosomal constitution was identified following amniocentesis. -- Three classes of images were observed: a trivalent, a trivalent presenting an important asynaptic region of the long arm, and a bivalent accompanied by a univalent. Such behaviour is analagous to that observed in all trisomic organisms. -- We have been able to establish the sequence of chromomeres, whose number varies from 9 to 14 according to the state of contraction in the 21 chromosome. Each band is thus subdivided into several sub-bands: at maximal elongation 2 sub-bands for band p11, 4 for q21 and 3 for q222. In addition, the interchromomeric clear bands q221 and q223 are also subdivided by the presence of a very small chromomere. In this way, the G-bands visible on mitotic metaphase chromosomes result from the compression together of several chromomeres whose individuality disappears as chromosomal condensation increases with progression of prophase.

References

Jan 1, 1975·Cytogenetics and Cell Genetics·T R Bigger, J R Savage
Jan 1, 1973·Advances in Human Genetics·M Hultén, J Lindsten
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D A HungerfordG Haller
Jan 1, 1971·Humangenetik·J SchröderA De la Chapelle
Feb 1, 1974·Journal of Reproduction and Fertility·J M LucianiA Stahl

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Citations

Apr 5, 1979·Chromosoma·T A Okada, D E Comings
Jan 1, 1984·Human Genetics·R M Speed
Jan 1, 1984·Human Genetics·J M LucianiM R Morazzani
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·E OlmoG Odierna
Jan 17, 2009·Reproductive Biomedicine Online·R Garcia-CruzM Garcia Caldés
Oct 1, 1983·Annals of Human Genetics·B M Wallace, M A Hultén
Sep 20, 2008·Molecular Cytogenetics·Maj A HulténErik Iwarsson
Apr 28, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·I RoigM Garcia
Jan 1, 1982·Human Genetics·P PolaniJ Kelberman
Feb 10, 2004·The Journal of Urology·Erica Schalow MercerCharlotte A Massad

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