Meiotic and mitotic recombination in meiosis

Genetics
Kathryn P Kohl, Jeff Sekelsky

Abstract

Meiotic crossovers facilitate the segregation of homologous chromosomes and increase genetic diversity. The formation of meiotic crossovers was previously posited to occur via two pathways, with the relative use of each pathway varying between organisms; however, this paradigm could not explain all crossovers, and many of the key proteins involved were unidentified. Recent studies that identify some of these proteins reinforce and expand the model of two meiotic crossover pathways. The results provide novel insights into the evolutionary origins of the pathways, suggesting that one is similar to a mitotic DNA repair pathway and the other evolved to incorporate special features unique to meiosis.

References

May 1, 1983·Cell·J W SzostakFranklin W Stahl
Dec 31, 1997·The Journal of Biological Chemistry·P PochartNancy M Hollingsworth
Jun 5, 1999·Microbiology and Molecular Biology Reviews : MMBR·F Pâques, J E Haber
Feb 26, 2000·Annual Review of Genetics·Denise Zickler, Nancy Kleckner
Jul 26, 2000·The Journal of Cell Biology·Jeff SekelskyK C Burtis
Nov 23, 2000·Biochemistry·A J van BrabantW K Holloman
Sep 27, 2001·Cell·Anne M Villeneuve, K J Hillers
Nov 15, 2003·Current Biology : CB·Beth RockmillG Shirleen Roeder
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mitch McVeyJeff Sekelsky
Dec 22, 2004·Genetics·Juan Lucas ArguesoEric Alani
Jul 15, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Edyta Marcon, Peter B Moens
Mar 9, 2006·Chromosoma·Esther de Boer, Christa Heyting
May 4, 2006·Nucleic Acids Research·Csanád Z BachratiIan D Hickson
Jul 14, 2006·Nature·Matthew J Neale, Scott Keeney
Aug 19, 2007·PLoS Genetics·Luke E BerchowitzGregory P Copenhaver
Apr 2, 2008·Cell Research·Xiaoduo LuChunyi Zhang
Nov 21, 2008·Nature·Stephen C Y IpStephen C West
Jan 14, 2009·Genetics·Adam S Wilkins, Robin Holliday
Oct 5, 2010·Current Genomics·Luke E Berchowitz, Gregory P Copenhaver
Mar 6, 2012·Nature Cell Biology·Francesca ColeMaria Jasin
Jun 23, 2012·Science·Wayne CrismaniRaphael Mercier
Sep 8, 2012·Annals of the New York Academy of Sciences·Francesca ColeMaria Jasin

Citations

Jul 23, 2013·PLoS Genetics·Stephanie P Bellendir, Jeff Sekelsky
Jan 29, 2014·International Journal of Molecular Sciences·Wang-Ren QiuKuo-Chen Chou
Feb 24, 2016·Seminars in Cell & Developmental Biology·Josef Loidl, Alexander Lorenz
Dec 22, 2015·Fungal Biology Reviews·Alexander IdnurmTatiana Giraud
Nov 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael LynchShelley Sazer
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Mathilde Séguéla-ArnaudRaphael Mercier
Nov 12, 2015·Fungal Genetics and Biology : FG & B·William G AlexanderChris Todd Hittinger
Jun 7, 2014·The Journal of Eukaryotic Microbiology·Jingyun ChiMicah Dunthorn
Nov 1, 2015·DNA Repair·Agnieszka LukaszewiczJosef Loidl
Jul 25, 2015·Reproductive Biomedicine Online·Sezgin GunesAshok Agarwal
Feb 18, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael F Seidl, Bart P H J Thomma
Mar 31, 2015·The FEBS Journal·Emily L Kurdzo, Dean S Dawson
Jun 26, 2015·FEMS Microbiology Reviews·Adrianna SkonecznaMarek Skoneczny
Aug 4, 2016·Frontiers in Cell and Developmental Biology·Alphy JohnJishy Varghese
Nov 30, 2018·Cell Cycle·J Brooks Crickard, Eric C Greene
Oct 1, 2016·Annual Review of Genetics·Josef Loidl
Dec 17, 2017·Genetics·Morgan M BradyJeff Sekelsky
Aug 10, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Talia Hatkevich, Jeff Sekelsky
Jun 21, 2014·Genetics·Michael LynchBernhard Haubold
Jun 9, 2016·Genetics·James A Birchler
Jan 7, 2021·Nucleic Acids Research·Talia HatkevichJeff Sekelsky

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