PMID: 11331634May 2, 2001Paper

Meiotic behaviour of the sex chromosomes in three patients with sex chromosome anomalies (47,XXY, mosaic 46,XY/47,XXY and 47,XYY) assessed by fluorescence in-situ hybridization

Human Reproduction
J BlancoF Vidal


Meiotic studies using multicolour fluorescent in-situ hybridization (FISH) and chromosome painting were carried out in three patients with sex chromosome anomalies (47,XXY; 46,XY/47,XXY and 47,XYY). In the two patients with Klinefelter syndrome, although variable percentages of XXY cells (88.5 and 28.3%) could be found in the pre-meiotic stages, none of the abnormal cells entered meiosis, and all pachytenes were XY. However, the abnormal testicular environment of these patients probably resulted in meiotic I non-disjunction, and a certain proportion of post-reductional cells were XY (18.3 and 1.7%). The fact that none of the spermatozoa were XY also suggests the existence of an arrest at the secondary spermatocyte or the spermatid level. In the XYY patient, most (95.9%) premeiotic cells were XYY. The percentage of XYY pachytenes was 57.9%. The sex chromosomes were either in close proximity (XYY) or the X chromosome was separated from the two Ys (X + YY). A high proportion (42.1%) of post-reductional germ cells were XY. However, only 0.11% of spermatozoa were disomic for the sex chromosomes. In this case, the data suggest the existence of an arrest of the abnormal cells at the primary and the secondary spermatocyte or the sperma...Continue Reading


Aug 30, 1976·Human Genetics·A C ChandleyJ A Robinson
Apr 4, 1970·Lancet·E P EvansH Hunter
Aug 1, 1970·Lancet·U TettenbornE Schwinger
Mar 1, 1973·Journal of Reproduction and Fertility·N E SkakkebaekM Mikkelsen
Feb 1, 1971·Annals of Human Genetics·M Hultén, P L Pearson
Mar 15, 1969·Nature·N E SkakkebaekR Hammen
Jan 1, 1983·Human Genetics·J EgozcueS Marina
Jan 1, 1984·Human Genetics·F VidalJ Egozcue
Jan 1, 1980·Cytogenetics and Cell Genetics·P S Burgoyne, F G Biddle
Jan 8, 1998·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·A J Solari, G Rey Valzacchi
Jan 15, 1998·Cancer Genetics and Cytogenetics·T EscuderoJ Egozcue
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·C ForestaC Scandellari
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·C ForestaA Ferlin
Sep 6, 2000·Trends in Genetics : TIG·G S Roeder, J M Bailis

❮ Previous
Next ❯


Sep 7, 2002·Fertility and Sterility·Brian DaleFulvio Zullo
Oct 31, 2002·Human Reproduction·J EgozcueF Vidal
Jan 21, 2010·Human Reproduction·G FullertonA Maheshwari
May 31, 2013·Molecular Human Reproduction·C TempladoA Estop
Feb 23, 2012·PloS One·Marieke de VriesPeter de Boer
Mar 19, 2013·European Journal of Endocrinology·L Aksglaede, A Juul
Aug 20, 2005·Asian Journal of Andrology·Zaida SarrateFrancesca Vidal
May 3, 2014·Annales d'endocrinologie·Ingrid PlottonHervé Lejeune
Jul 5, 2013·Molecular Cytogenetics·Aránzazu Margallo BalseraRaquel Rodríguez-López
Dec 30, 2014·Human Fertility : Journal of the British Fertility Society·Minh Huong NguyenAurore Perrin
Jul 4, 2012·Fertility and Sterility·Merel MaiburgJacques Giltay
Aug 13, 2011·Gynécologie, obstétrique & fertilité·C RavelI Berthaut
Sep 1, 2005·International Journal of Andrology·Nathalie RivesBertrand Macé
Jun 16, 2011·Andrologia·M M Abdel-RazicE S ElSobky
Jun 18, 2011·Stem Cells·C EguizabalJ C Izpisua Belmonte
Jan 9, 2003·The Urologic Clinics of North America·Paul J Turek, Renee A Reijo Pera
Jun 18, 2015·Journal of Assisted Reproduction and Genetics·Alisa Komsky-ElbazDeborah Strassburger
Sep 30, 2005·Cytogenetic and Genome Research·J EgozcueF Vidal
Sep 30, 2005·Cytogenetic and Genome Research·M Oliver-BonetR H Martin
Apr 17, 2012·PloS One·Woei Chang LiewLaszlo Orban
Apr 22, 2008·The Urologic Clinics of North America·Robert D Oates
Feb 22, 2014·Lancet Neurology·David S Hong, Allan L Reiss
Sep 8, 2009·The Journal of Pediatrics·C M GirardinG Van Vliet
Dec 15, 2010·Cytogenetic and Genome Research·A PintonA Ducos
Feb 2, 2011·Cytogenetic and Genome Research·C TempladoA Estop
May 2, 2006·Current Opinion in Genetics & Development·Heather HallTerry Hassold

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.