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Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth hormone gene expression in rat MtT/S somatotroph cells

Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih

Aug 9, 2008

Feng-Ying GongYi-Fan Shi

PMID: 18686625

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Abstract

To investigate the effect of interleukin-6 (IL-6) on the human growth hormone (hGH) gene expression in a rat somatotropic pituitary cell line MtT/S. The plasmids containing various lengths of hGH gene 5'-promoter fragments were constructed. Stably transfected MtT/S cells were created by...read more

Mentioned in this Paper

Pathologic Cytolysis
Biochemical Pathway
Transfection
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 14
Somatotrophs
Gene Deletion Abnormality
Transduction
Promoter
Gene Expression
Paper Details
References
  • References22
  • Citations1
123
  • References22
  • Citations1
1

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Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth hormone gene expression in rat MtT/S somatotroph cells

Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih

Aug 9, 2008

Feng-Ying GongYi-Fan Shi

PMID: 18686625

DOI:

Abstract

To investigate the effect of interleukin-6 (IL-6) on the human growth hormone (hGH) gene expression in a rat somatotropic pituitary cell line MtT/S. The plasmids containing various lengths of hGH gene 5'-promoter fragments were constructed. Stably transfected MtT/S cells were created by...read more

Mentioned in this Paper

Pathologic Cytolysis
Biochemical Pathway
Transfection
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 14
Somatotrophs
Gene Deletion Abnormality
Transduction
Promoter
Gene Expression

Feeds With Similar Papers

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

MAPK Pathway

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

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Paper Details
References
  • References22
  • Citations1
123
  • References22
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