Melan-A positive dermal cells in malignant melanoma in situ

Journal of Cutaneous Pathology
Mary Elizabeth DangaJag Bhawan

Abstract

The presence of Melan-A positive dermal cells in excisions for melanoma in situ represents a frequent conundrum for pathologists. These cells may represent superficially invasive melanoma, benign, incidental, dermal nevi or non-specific staining of dermal melanophages. Occasionally, rare, Melan-A positive dermal cells are present which do not clearly correspond to the above three categories. Our objective was to further characterize these Melan-A positive dermal cells. To do this, immunoperoxidase staining for Melan-A and SOX-10 was performed on 188-cutaneous excisions, including examples of melanoma in situ, atypical junctional melanocytic hyperplasia and non-melanocytic tumors. These were evaluated for the presence of Melan-A and SOX-10 positive dermal cells. Dermal cells, positive for both markers, were identified in 17% of the excisions. The cells were present in 10% of cases from the melanocytic group and 31% of the cases from the non-melanocytic group. These cells did not exhibit cytologic atypia and resembled neither the co-existing neoplasm nor melanophages. We conclude that positivity of these rare Melan-A positive cells for SOX-10 argues that they represent true melanocytes and not non-specific staining. The absence o...Continue Reading

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Citations

Aug 16, 2016·Veterinary Ophthalmology·Amanda B ShermanBrian C Gilger
Dec 5, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Stewart F CramerMiguel Reyes-Múgica
Apr 6, 2019·Journal of Cutaneous Pathology·Emily L BehrensMichelle Tarbox
May 8, 2020·Melanoma Research·Claire Audrey-BayanYvonne M Saenger
Nov 1, 2015·Melanoma Management·Shadi Damanpour, James M Grichnik
Jan 16, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xintao YangMartin Cheung
Feb 7, 2021·Journal of Cutaneous Pathology·Soha GhanianJoanna Walker
Apr 3, 2021·The American Journal of Dermatopathology·Tony C Chen, Michael G Hitchcock

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