Melanin pigmentation in mammalian skin and its hormonal regulation

Physiological Reviews
Andrzej SlominskiJacobo Wortsman

Abstract

Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents interacting via pathways activated by receptor-dependent and -independent mechanisms, in hormonal, auto-, para-, or intracrine fashion. Because of the multidirectional nature and heterogeneous character of the melanogenesis modifying agents, its controlling factors are not organized into simple linear sequences, but they interphase instead in a multidimensional network, with extensive functional overlapping with connections arranged both in series and in parallel. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortins and ACTH, whereas among the negative regulators agouti protein stands out, determining intensity of melanogenesis and also the type of melanin synthesized. Within the context of the skin as a stress organ, melanogenic activity serves as a unique molecular sensor and transducer of noxious signals and as regulator of local homeostasis. In keeping with these multiple roles, melanogenesis is controlled by a highly structured system, active since earl...Continue Reading

References

Mar 1, 1978·Journal of Cellular Physiology·X O BreakefieldR Shiman
Nov 1, 1978·The Journal of Investigative Dermatology·A Logan, B Weatherhead
Oct 1, 1979·Journal of the American Academy of Dermatology·M R Okun, J Bhawan
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J PawelekJ M Varga
Dec 11, 1975·Nature·J PawelekG Christie
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J M VargaA B Lerner
Apr 1, 1976·The Journal of Investigative Dermatology·J M Pawelek
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A DiPasqualeJ M Varga
Jan 1, 1979·General and Comparative Endocrinology·M D Davis, M E Hadley
Jan 1, 1978·Annual Review of Biochemistry·L Stryer
Mar 1, 1978·The Journal of Investigative Dermatology·I K Rosdahl, G Szabó
Aug 18, 1978·Science·R F Branda, J W Eaton
Oct 1, 1976·The Journal of Investigative Dermatology·K OkazakiM Seiji
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·J J Nordlund, A B Lerner
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E P ToffolonK Isselbacher
Jan 1, 1975·Archives of Dermatology·A M Kligman, I Willis
Nov 1, 1992·Pigment Cell Research·J M PawelekJ L Bolognia
Jan 1, 1992·Archives of Dermatological Research·N Bech-ThomsenH C Wulf
Jan 1, 1992·Archives of Dermatological Research·A Ramirez-BoscaH Holzmann
Jun 1, 1992·Nature Genetics·R Johnson, I J Jackson
Apr 1, 1992·The Journal of Investigative Dermatology·V SteinkrausH Mensing
Mar 1, 1992·The British Journal of Dermatology·J S PearsA J Thody
May 1, 1992·Journal of the American Academy of Dermatology·N MozzanicaA F Finzi
Mar 1, 1992·Pigment Cell Research·A MorroneF Ippolito
Sep 1, 1992·The British Journal of Dermatology·J P Ortonne
Jan 1, 1992·Progress in Histochemistry and Cytochemistry·W SiegristA N Eberle
Nov 30, 1992·Biochemical and Biophysical Research Communications·K U SchallreuterA J Thody
Apr 1, 1992·Experimental Cell Research·A J Winder, H Harris
Dec 24, 1992·Cell·S J BultmanR P Woychik
Dec 1, 1992·Pigment Cell Research·A Slominski, T Friedrich
Aug 25, 1992·Biochimica Et Biophysica Acta·A Slominski, D Pruski

❮ Previous
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Citations

Nov 23, 2011·Archives of Dermatology·Cynthia M MagroJonathan H Zippin
Jun 16, 2010·Archives of Dermatological Research·Sungran HuhDeokhoon Park
Sep 18, 2010·Archives of Dermatological Research·Ho Sik RhoJae Sung Hwang
Dec 31, 2010·Archives of Pharmacal Research·Te-Sheng Chang, Jia-Jhen Lin
Sep 13, 2011·Archives of Pharmacal Research·Ji Young YunYoungsoo Kim
Aug 6, 2013·American Journal of Clinical Dermatology·Carlos R Camara-Lemarroy, Julio C Salas-Alanis
Dec 17, 2008·Journal of the American Society for Mass Spectrometry·Krystyna StepieńIrena Tam
Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Aleksandra Kawczyk-KrupkaAleksander Sieroń
Nov 3, 2011·Expert Reviews in Molecular Medicine·Ivan PachecoVictor Tron
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C B KaelinG S Barsh
Feb 15, 2011·The Journal of Biological Chemistry·Hsiang HoAnand K Ganesan
Jun 24, 2008·Natural Product Research·Snitmatjaro Nattapong, Luanratana Omboon
Apr 9, 2009·International Journal of Epidemiology·Marina KvaskoffMarie-Christine Boutron-Ruault
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sobia KauserDesmond J Tobin
Apr 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pawel MrozMichael R Hamblin
Nov 27, 2008·The American Journal of Dermatopathology·Jessin BlossomJ Andrew Carlson
Oct 18, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Woo Jin YunSung Eun Chang
May 31, 2008·Development, Growth & Differentiation·Aya Nishiyama, Shigeki Fujiwara
Feb 20, 2008·Photochemistry and Photobiology·M E CanoC F O Graeff
Mar 19, 2008·Photochemistry and Photobiology·Dan-Ning HuTadeusz Sarna
Apr 23, 2008·Pigment Cell & Melanoma Research·Kevin J McGraw
Jan 30, 2009·Pigment Cell & Melanoma Research·Andrzej Slominski
Oct 21, 2010·Pigment Cell & Melanoma Research·Karin U SchallreuterHartmut Rokos
Nov 13, 2010·Pigment Cell & Melanoma Research·Desmond J Tobin
Nov 27, 2010·Pigment Cell & Melanoma Research·Ralf Paus
Jul 23, 2011·Pigment Cell & Melanoma Research·Hsiang Ho, Anand K Ganesan
Aug 13, 2011·Pigment Cell & Melanoma Research·Andrzej SlominskiJohn Pawelek
Jul 10, 2009·American Journal of Physiology. Cell Physiology·Sulochana DeviVijayasaradhi Setaluri
Jun 16, 2011·American Journal of Physiology. Endocrinology and Metabolism·Cezary SkobowiatAndrzej Slominski
Oct 6, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Andrzej Slominski
Sep 15, 2007·Folia primatologica; international journal of primatology·Jonathan Kingdon
Nov 3, 2007·The Journal of Clinical Investigation·Andrzej Slominski
May 25, 2007·BMC Developmental Biology·Gufa LinJonathan M W Slack

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