Abstract
The relationship between skin cancer and non-Hodgkin lymphoma (NHL) suggests common genetic, host or environmental causes. Ultraviolet radiation (UVR), pigmentary characteristics have been linked with both malignancies, and for skin cancer, the melanocortin 1 receptor (MC1R) which influences pigmentation has also been implicated. This paper reports on the relationship between MC1R, skin, hair and eye colour, time spent outdoors, and diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Persons carrying MC1R homozygote variant alleles at R151C, R160W, D294H and D84E were more likely to have fair skin, red hair and to spend less time outdoors than those who did not. The variant allele at V92M was associated with FL (odds ratio (OR)=1.61, 95% confidence interval (CI) 1.08-2.39) and the r:wild type genotype with DLBCL (OR=0.58, 95% CI 0.38-0.89). Interactions between MC1R genotypes and skin colour influenced DLBCL risk; the RR genotype increased risk in individuals with medium or dark skin, based on 5 cases and no controls, but decreased risk among those of fair skin. On the whole, DLBCL and FL risk were not related to genetic variation in MC1R, pigmentation or time spent outdoors.
References
Aug 15, 1992·Cancer·T ZhengJ Flannery
Nov 1, 1995·Nature Genetics·P ValverdeA J Thody
Oct 1, 1996·Human Molecular Genetics·P ValverdeJ L Rees
May 17, 1997·BMJ : British Medical Journal·D M FreedmanM Dosemeci
Apr 1, 2000·Lancet·E HealyJ L Rees
May 18, 2000·Archives of Dermatology·K Hemminki, C Dong
Oct 13, 2000·Human Molecular Genetics·N FlanaganJ L Rees
Mar 10, 2001·Cancer·W B GogginsH Tsao
Jun 20, 2001·Journal of Occupational and Environmental Medicine·E van Wijngaarden, D A Savitz
Aug 16, 2001·Epidemiology·N HåkanssonN Hallin
Oct 17, 2001·Gene·R A SturmN F Box
Jun 20, 2002·The British Journal of Dermatology·T W DaviesN E Day
Apr 20, 2004·International Journal of Cancer. Journal International Du Cancer·Ann Maree HughesAnne Kricker
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Ann Maree HughesAnne Kricker
Oct 1, 2004·Cancer Causes & Control : CCC·Eleanor V WillettEve Roman
Feb 3, 2005·Journal of the National Cancer Institute·Karin Ekström SmedbyHans-Olov Adami
Jun 24, 2005·Human Molecular Genetics·Kimberley A BeaumontRichard A Sturm
Aug 17, 2006·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Alessandra TavaniCarlo La Vecchia
Aug 26, 2006·Cancer Causes & Control : CCC·Patricia HartgeScott Davis
Feb 7, 2007·Human Mutation·Meg R GerstenblithMaria Teresa Landi
Feb 22, 2007·International Journal of Cancer. Journal International Du Cancer·Thomas WeihkopfAndreas Seidler
Aug 10, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lori K SoniBrian C-H Chiu
Aug 22, 2007·International Journal of Cancer. Journal International Du Cancer·Anne KrickerUNKNOWN Interlymph Consortium
Nov 28, 2007·Cancer Causes & Control : CCC·L GrandinJ Clavel
Nov 30, 2007·American Journal of Physical Anthropology·Esteban J Parra
May 17, 2008·PLoS Genetics·Jiali HanDavid J Hunter
Feb 12, 2009·Annals of Human Genetics·Wojciech BranickiAnna Wojas-Pelc
Apr 28, 2009·Cancer Causes & Control : CCC·Allison H GathanySophia S Wang
Jul 9, 2009·Human Genetics·Kathrine Damm Meyle, Per Guldberg
Aug 4, 2009·PloS One·Daniel GlassVeronique Bataille
Dec 5, 2009·British Journal of Haematology·Alexandra SmithUNKNOWN Haematological Malignancy Research Network
Citations
Sep 27, 2014·International Journal of Cancer. Journal International Du Cancer·Elizabeth K CahoonD Michal Freedman
May 9, 2014·Pigment Cell & Melanoma Research·Jose C García-BorrónCelia Jiménez-Cervantes
Oct 6, 2017·Oncotarget·Demin LuSuZhan Zhang
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marit Bragelien VeierødElisabete Weiderpass
Feb 20, 2021·Cancer Causes & Control : CCC·Hong-Bae Kim, Jung-Ha Kim