Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands.

Pigment Cell & Melanoma Research
Kimberley A BeaumontRichard A Sturm

Abstract

Binding of melanocortin peptide agonists to the melanocortin-1 receptor of melanocytes results in eumelanin production, whereas binding of the agouti signalling protein inverse agonist results in pheomelanin synthesis. Recently, a novel melanocortin-1 receptor ligand was reported. A β-defensin gene mutation was found to be responsible for black coat colour in domestic dogs. Notably, the human equivalent, β-defensin 3, was found to bind with high affinity to the melanocortin-1 receptor; however, the action of β-defensin as an agonist or antagonist was unknown. Here, we use in vitro assays to show that β-defensin 3 is able to act as a weak partial agonist for cAMP signalling in human embryonic kidney (HEK) cells expressing human melanocortin-1 receptor. β-defensin 3 is also able to activate MAPK signalling in HEK cells stably expressing either wild type or variant melanocortin-1 receptors. We suggest that β-defensin 3 may be a novel melanocortin-1 receptor agonist involved in regulating melanocyte responses in humans.

References

Nov 22, 2000·The Journal of Biological Chemistry·J HarderJ M Schroder
Feb 11, 2005·Journal of Molecular Biology·Joseph C McNultyGlenn L Millhauser
Oct 18, 2005·Peptides·Haiqin ChenPeilin Cen
Jul 10, 2007·Human Molecular Genetics·Kimberley A BeaumontRichard A Sturm
Oct 20, 2007·Science·Sophie I CandilleGregory S Barsh
Sep 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Karine ClémentJuliane Leger
Feb 7, 2009·Science·Tovi M AndersonGregory S Barsh
Apr 4, 2009·The Journal of Allergy and Clinical Immunology·Regine GläserThomas Schwarz
Jan 1, 2009·Progress in Molecular Biology and Translational Science·Kimberley A BeaumontRichard A Sturm
Jan 5, 2011·European Journal of Pharmacology·Kimberley A BeaumontRichard A Sturm

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Citations

Mar 26, 2013·Cellular and Molecular Life Sciences : CMLS·Jennifer J SmithPaul F Alewood
Jun 5, 2013·The Journal of Investigative Dermatology·Claire Q F WangJames G Krueger
Jan 17, 2013·The Journal of Investigative Dermatology·Herlina Y HandokoGraeme J Walker
Oct 5, 2015·Bioorganic & Medicinal Chemistry Letters·Mark D EricsonCarrie Haskell-Luevano
May 9, 2014·Pigment Cell & Melanoma Research·Jose C García-BorrónCelia Jiménez-Cervantes
Jun 27, 2015·Frontiers in Neuroscience·David S JacksonLi F Chan
Jun 26, 2013·Chemistry & Biology·Matthew A NixGlenn L Millhauser
Jun 16, 2016·Frontiers in Genetics·Erin M Wolf HorrellJohn A D'Orazio
Mar 5, 2016·Journal of Molecular Endocrinology·Erica J P AndersonMichael J Litt
Feb 6, 2015·F1000Research·Erin Wolf Horrell, John D'Orazio
Feb 6, 2015·F1000Research·Erin Wolf Horrell, John D'Orazio
Nov 13, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shelly AonoEdward E Morrison

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