Melanocortin-3 receptor regulates the normal fasting response.

Proceedings of the National Academy of Sciences of the United States of America
Benjamin J RenquistR D Cone

Abstract

The melanocortin-3 receptor-deficient (MC3-R(-/-)) mouse exhibits mild obesity without hyperphagia or hypometabolism. MC3-R deletion is reported to increase adiposity, reduce lean mass and white adipose tissue inflammation, and increase sensitivity to salt-induced hypertension. We show here that the MC3-R(-/-) mouse exhibits defective fasting-induced white adipose tissue lipolysis, fasting-induced liver triglyceride accumulation, fasting-induced refeeding, and fasting-induced regulation of the adipostatic and hypothalamic-adrenal-pituitary axes. Close examination of the hypothalamic-pituitary-adrenal axis showed that MC3-R(-/-) mice exhibit elevated nadir corticosterone as well as a blunted fasting-induced activation of the axis. The previously described phenotypes of this animal and the reduced bone density reported here parallel those of Cushing syndrome. Thus, MC3-R is required for communicating nutritional status to both central and peripheral tissues involved in nutrient partitioning, and this defect explains much of the metabolic phenotype in the model.

References

Jan 1, 1975·Neuroendocrinology·W C Engeland, M F Dallman
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A PenhoatJ M Saez
Feb 1, 1994·Molecular and Cellular Endocrinology·K G MountjoyR D Cone
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L Roselli-RehfussR D Cone
Mar 4, 1998·Neuroendocrinology·S L WardlawI M Conwell
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·H RaffJ W Findling
Jul 21, 2000·The Journal of Clinical Investigation·I S FarooqiS O'Rahilly
Sep 21, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P Björntorp, R Rosmond
Oct 4, 2000·Nature Genetics
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R F KleinE S Orwoll
Apr 18, 2001·Brain Research Bulletin·H Shi, T J Bartness
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Jan 22, 2003·Biochemical and Biophysical Research Communications·W S DhilloS R Bloom
Feb 13, 2003·American Journal of Physiology. Endocrinology and Metabolism·Gabriella Segal-LiebermanEleftheria Maratos-Flier
Mar 18, 2003·Endocrinology·Daniel L MarksRoger D Cone
Apr 17, 2003·The Journal of Clinical Investigation·Xi-Ping NiMichael H Humphreys
May 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Peter Sartipy, David J Loskutoff
Jan 13, 2004·Science·Robert F KleinEric S Orwoll
May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert R BowersTimothy J Bartness
Apr 16, 2005·Cerebrovascular Diseases·James W SchmidleyLaura Trigg
Apr 28, 2005·Nature Neuroscience·Roger D Cone
Aug 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yubin ZhangThomas W Gettys
Oct 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Nov 1, 2006·The Journal of Biological Chemistry·Martina SchweigerRobert Zimmermann
Dec 30, 2006·Peptides·Serge LuquetRichard D Palmiter
Jan 11, 2007·Biochemical and Biophysical Research Communications·Takayoshi SuganamiYoshihiro Ogawa
Sep 22, 2007·The Journal of Clinical Investigation·Ruben NogueirasMatthias H Tschöp

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Citations

Sep 18, 2014·Journal of Molecular Endocrinology·Hui Huang, Ya-Xiong Tao
Jul 1, 2014·The American Journal of Pathology·Trinidad Montero-MelendezMauro Perretti
Jan 29, 2016·Nature Communications·Bonggi LeeJack A Yanovski
Nov 28, 2012·Trends in Endocrinology and Metabolism : TEM·James P Warne, Allison W Xu
Oct 7, 2015·Frontiers in Endocrinology·Danaé NuzzaciAlexandre Benani
Apr 12, 2016·Journal of Cachexia, Sarcopenia and Muscle·Ana Belen Gómez-SanMiguelAsunción López-Calderón
May 18, 2013·Biochimica Et Biophysica Acta·Clemence Girardet, Andrew A Butler
Oct 1, 2013·Current Opinion in Pharmacology·Anthony P Coll, Giles S H Yeo
Jul 1, 2015·Nature Reviews. Endocrinology·Denis Richard
Oct 28, 2011·Nutrition & Metabolism·Rainer J Klement, Ulrike Kämmerer
Dec 30, 2014·Frontiers in Physiology·Jung D KimSabrina Diano
Mar 5, 2016·Journal of Molecular Endocrinology·Erica J P AndersonMichael J Litt
Aug 3, 2018·Pflügers Archiv : European journal of physiology·Lærke BertholdtHenriette Pilegaard
Feb 28, 2019·The Journal of Endocrinology·Giulia Baldini, Kevin D Phelan
Jul 15, 2018·The Journal of Endocrinology·Kim EerolaEriika Savontaus
Feb 15, 2018·EMBO Reports·Aygul SubkhangulovaThomas E Willnow
Mar 5, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chelsea HeplerBenjamin J Renquist
Apr 1, 2017·Frontiers in Neuroscience·Andrew A ButlerSusan A Farr
Aug 25, 2018·Science Advances·Masoud Ghamari-LangroudiRoger D Cone
Oct 12, 2018·The Journal of Endocrinology·K EerolaE Savontaus
Jul 1, 2014·International Journal of Obesity Supplements·C GirardetA A Butler
Dec 16, 2020·International Journal of Molecular Sciences·Maite Martínez-UñaMarta G Novelle
Nov 19, 2020·Nutrients·Emanuela Micioni Di BonaventuraCarlo Cifani
Feb 9, 2021·Research Synthesis Methods·Stevie Van der MierdenCathalijn H C Leenaars
Mar 7, 2021·International Journal of Molecular Sciences·Yetirajam Rajesh, Devanand Sarkar
Aug 10, 2021·Neuropharmacology·Anna I DuniganAaron G Roseberry
Aug 18, 2021·Molecular Metabolism·Yunpeng LiChao Zhang

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