Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning.

Physiology & Behavior
H CuiM Lutter

Abstract

It is now widely recognized that exposure to palatable foods engages reward circuits that promote over-eating and facilitate the development of obesity. While the melanocortin 4 receptor (MC4R) has previously been shown to regulate food intake and energy expenditure, little is known about its role in food reward. We demonstrate that MC4R is co-expressed with the dopamine 1 receptor (D1R) in the ventral striatum. While MC4R-null mice are hyperphagic and obese, they exhibit impairments in acquisition of operant responding for a high fat reinforcement. Restoration of MC4R signaling in D1R neurons normalizes procedural learning without affecting motivation to obtain high fat diet. MC4R signaling in D1R neurons is also required for learning in a non-food-reinforced version of the cued water maze. Finally, MC4R signaling in neostriatal slices increases phosphorylation of the Thr34 residue of DARPP-32, a protein phosphatase-1 inhibitor that regulates synaptic plasticity. These data identify a novel requirement for MC4R signaling in procedural memory learning.

Associated Clinical Trials

References

Nov 1, 1984·Clinics in Endocrinology and Metabolism·N J Rothwell, M J Stock
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Jan 24, 2003·The Journal of Comparative Neurology·Toshiro KishiJoel K Elmquist
Mar 21, 2003·The New England Journal of Medicine·I Sadaf FarooqiStephen O'Rahilly
Jan 10, 2004·Journal of Neurochemistry·Ryuichi FukuiAkinori Nishi
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Per SvenningssonPaul Greengard
Aug 18, 2004·Journal of Neurochemistry·Miho HamadaAkinori Nishi
Oct 7, 2004·Neuropharmacology·Angus C NairnPaul Greengard
Jan 12, 2005·Physiology & Behavior·C H VaughanN E Rowland
May 5, 2005·The European Journal of Neuroscience·Richard HsuRonald S Duman
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher PittengerRiccardo Brambilla
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Susana PeciñaKent C Berridge
Mar 23, 2007·Annual Review of Neuroscience·Howard L FieldsSaleem M Nicola
Jun 15, 2007·Neuroscience and Biobehavioral Reviews·Graham FinlaysonJohn E Blundell
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexis FaureKent C Berridge
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anni S LeeChristopher Pittenger
Jan 30, 2009·The Journal of Nutrition·Michael Lutter, Eric J Nestler
Dec 26, 2009·Biological Psychiatry·Mario PerelloJeffrey M Zigman
Mar 20, 2010·Journal of Neurochemistry·Masato HaraAkinori Nishi
Apr 9, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deniz AtalayerNeil E Rowland
Apr 15, 2010·Brain Research·Kent C BerridgeAlexandra G DiFeliceantonio
Aug 10, 2010·Neuroscience Letters·Lissandra C Baldan Ramsey, Christopher Pittenger
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mario PerelloMichael Lutter
Nov 27, 2010·Trends in Cognitive Sciences·Nora D VolkowRuben D Baler
Mar 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hans-Rudolf BerthoudAndrew C Shin
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jocelyn M Richard, Kent C Berridge

❮ Previous
Next ❯

Citations

Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Pin XuAndrew A Pieper
Jan 28, 2016·Nature Neuroscience·Michael J KrashesAlastair S Garfield
Sep 29, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N D VolkowR D Baler
Jul 23, 2013·European Journal of Pharmacology·Joram D MulRoger A H Adan
Jul 23, 2013·European Journal of Pharmacology·R PanditR A H Adan
Jun 18, 2014·The International Journal of Neuropsychopharmacology·Sarah Pol BodettoPatrick Anglard
Apr 12, 2014·Frontiers in Neuroanatomy·Ralph J A Oude OphuisRoger A H Adan
May 16, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Z YilmazJ L Kennedy
Oct 22, 2016·Molecular and Cellular Endocrinology·Kavya Devarakonda, Charles V Mobbs
Feb 28, 2019·The Journal of Endocrinology·Giulia Baldini, Kevin D Phelan
Mar 4, 2014·Nature Reviews. Neuroscience·Vanni CarusoHelgi B Schiöth
Jan 3, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina Roth MotaAlejandro Arias Vásquez
Oct 20, 2015·Current Psychiatry Reports·Nina CarlierDaniel J Müller
Aug 20, 2017·Scientific Reports·Anthony M ChomykRanjan Dutta
Jun 19, 2018·The Journal of Clinical Investigation·Anna Mathia KlawonnDavid Engblom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.