Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy

Current Drug Targets. Inflammation and Allergy
Connie W Lam, Stephen J Getting

Abstract

Alpha-melanocyte stimulating hormone (alpha-MSH) and other melanocortin peptides are potent anti-inflammatory agents exhibiting efficacy in many animal models of acute and chronic inflammation. They are derived from a larger precursor molecule known as the POMC prohormone and are produced both centrally and peripherally. They exert their effect by binding to melanocortin receptors, of which five have been cloned and partially characterised. Agonism at these receptors leads to adenylate cyclase activation and subsequent increases in cAMP formation. Two receptors to date have been proposed to mediate the actions of the melanocortin peptides in an inflammatory scenario, the MC1 and 3-R, and here we discuss our findings proposing the MC3-R as a novel therapeutic target. The potential anti-inflammatory role for MC3-R is in its infancy, however, recent studies have shown that melanocortin peptides are effective in mice bearing a non-functional MC1-R (recessive yellow e/e mice). This ability to inhibit cell migration appears to be via inhibition in cytokine and adhesion molecule expression and is due to their abilities to interfere with cell signalling pathways. Identification of endogenous mediators of anti-inflammation, their recept...Continue Reading

Citations

Nov 21, 2007·Annals of the Rheumatic Diseases·Thomas A Luger, Thomas Brzoska
Apr 5, 2008·Journal of Leukocyte Biology·Dayu Li, Andrew W Taylor
Dec 26, 2006·Regulatory Peptides·Biaoxin ChaiMichael W Mulholland
Jun 20, 2006·Medical Hypotheses·E A HammingaH B Thio
Jan 31, 2006·European Journal of Pharmacology·Stephen J GettingMauro Perretti
Sep 13, 2005·Journal of Neuroimmunology·Ruta MucenieceMaija Dambrova
Apr 23, 2015·Experimental Biology and Medicine·Yang YangYang Zheng
Oct 17, 2006·Journal of Leukocyte Biology·Anna Catania
Mar 8, 2008·Nature Reviews. Drug Discovery·Jarl E S Wikberg, Felikss Mutulis
Feb 23, 2021·Ocular Immunology and Inflammation·Tat Fong NgAndrew W Taylor
May 29, 2010·ACS Nano·Florence FiorettiNadia Benkirane-Jessel

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