Melanocortin receptors and their accessory proteins.

Molecular and Cellular Endocrinology
Sadani N Cooray, Adrian J L Clark

Abstract

The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function. Like these GPCRs the melanocortin receptor family is also known to be associated with accessory proteins that regulate their function. In this review we will summarise the accessory proteins involved in the function of the 5 melanocortin receptors and in particular focus on the melanocortin 2 receptor accessory protein (MRAP) which is crucial for the function of the MC2R.

References

Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·R A StarJ M Lipton
Apr 1, 1994·Journal of Molecular Endocrinology·P BarrettP Morgan
Apr 29, 1994·Biochemical and Biophysical Research Communications·N GriffonP Sokoloff
May 16, 1994·Biochemical and Biophysical Research Communications·I GantzT Yamada
Sep 15, 1993·Biochemical and Biophysical Research Communications·V ChhajlaniJ E Wikberg
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L Roselli-RehfussR D Cone
Jul 1, 1996·The Journal of Clinical Endocrinology and Metabolism·A SlominskiM Mihm
Mar 1, 1997·Molecular Endocrinology·Y K YangI Gantz
Jun 24, 1998·Brain Research. Developmental Brain Research·K G Mountjoy, J M Wild
Dec 23, 1998·Endocrine Reviews·A J Clark, A Weber
Jun 1, 1999·Journal of Neurochemistry·A A GimelbrantT S McClintock
May 19, 2000·Annals of the New York Academy of Sciences·B A Boston
Jul 21, 2000·The Journal of Clinical Investigation·I S FarooqiS O'Rahilly
Oct 12, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J E WikbergA Skottner
Apr 21, 2001·Cellular and Molecular Life Sciences : CMLS·Z A Abdel-Malek
Jun 11, 2002·Biochemical and Biophysical Research Communications·Aimin XuGarth J S Cooper
Nov 26, 2002·The Journal of Biological Chemistry·Arthur ChristopoulosPatrick M Sexton
Jan 31, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ira Gantz, Tung M Fong
May 20, 2004·European Urology·William J Martin, D Euan MacIntyre

❮ Previous
Next ❯

Citations

Aug 3, 2013·Journal of Molecular Endocrinology·A R RodriguesA M Gouveia
Mar 19, 2014·Psychoneuroendocrinology·Russell D RomeoIlia N Karatsoreos
Jun 6, 2013·International Journal of Inflammation·Tazeen J AhmedCostantino Pitzalis
May 20, 2014·General and Comparative Endocrinology·Yuki KobayashiAkiyoshi Takahashi
Jul 16, 2014·Molecular and Cellular Endocrinology·Elise BouwPatric J D Delhanty
Feb 2, 2013·General and Comparative Endocrinology·Ravisankar ValsalanHelgi B Schiöth
Sep 3, 2013·Biochemical and Biophysical Research Communications·Nam Soo KimSang Hoon Kim
Nov 28, 2012·Molecular and Cellular Endocrinology·Shin Y ParkFrancesca Spiga
Feb 16, 2013·General and Comparative Endocrinology·J M Cerdá-ReverterM Eley
Aug 9, 2012·Molecular and Cellular Endocrinology·Adriana R RodriguesAlexandra M Gouveia
Dec 17, 2014·Cellular and Molecular Life Sciences : CMLS·Adriana R RodriguesAlexandra M Gouveia
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Russell D RomeoVeronica M So
Jan 23, 2016·Journal of Molecular Endocrinology·Nicole Gallo-Payet
May 7, 2016·Journal of Molecular Endocrinology·Gunnar KleinauHeike Biebermann
Jul 5, 2016·Scientific Reports·Uniza Wahid KhanDag Inge Våge
Mar 4, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gergely TalaberSam Okret
Sep 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Darren J Lee, Andrew W Taylor
Feb 24, 2017·Frontiers in Endocrinology·Chiraz GhaddhabJohnny Deladoëy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.