Melanocytes and iris color. Electron microscopic findings

Archives of Ophthalmology
P D ImeschI H Wallow

Abstract

To quantitatively associate iris color with melanocyte pigment content. Autopsy eyes were classified as uniform-blue, uniform-hazel, or uniform-brown or showing a darker peripupillary ring. Using electron microscopic images and computerized image analysis, area, number, and size of mature melanosomes within the perinuclear cytoplasmic area only or within perinuclear and peripheral cytoplasmic areas of the superficial stromal melanocytes combined were measured. Average melanosomal area per perinuclear cytoplasmic area (AMAC) and average number of melanosomes per perinuclear area (AMNC) significantly differed across iris color groups (overall P<.001). This result reflects the large difference between blue-uniform and all other color groups. A marginally significant (nominal) trend from blue-ring through brown-ring was also detected (P=.06 for AMAC and P=.07 for AMNC). The average perinuclear cytoplasmic area was larger in the central iris zone (within 1 mm around the pupillary margin) than in the intermediate iris zone (between 1 and 2 mm around the pupillary margin) (P=.002), but AMAC and AMNC did not significantly differ between zones. The average melanosome size did not differ significantly across color groups (P=.11). Differe...Continue Reading

Citations

Feb 27, 2001·Current Opinion in Ophthalmology·I GriersonN Pfeiffer
Sep 11, 2004·Pigment Cell Research·Despina KokkinouUlrich Schraermeyer
Sep 3, 2013·Journal of Cellular and Molecular Medicine·María José LuesmaLaurenţiu M Popescu
Feb 26, 2016·Royal Society Open Science·Melissa EdwardsEsteban J Parra
Mar 21, 2008·Pigment Cell & Melanoma Research·Kazumasa WakamatsuShosuke Ito
Dec 24, 2018·Scientific Reports·Lavinia Postolache, Cameron F Parsa
Oct 28, 1999·Current Opinion in Ophthalmology·W C Stewart
May 11, 2007·Veterinary Pathology·M K ZarfossR R Dubielzig
Jul 22, 2009·Pigment Cell & Melanoma Research·Richard A Sturm, Mats Larsson
Aug 3, 2011·Journal of Biomedical Optics·José M MedinaSergio M C Nascimento
Dec 24, 2010·Clinical & Experimental Ophthalmology·David A MackeyAlex W Hewitt
Mar 9, 2017·The British Journal of Ophthalmology·Victor KohChing-Yu Cheng
Mar 19, 2008·Photochemistry and Photobiology·Dan-Ning HuTadeusz Sarna
Aug 30, 2017·International Journal of Molecular Medicine·Nunzia CaporarelloCarmelina Daniela Anfuso
Dec 22, 2017·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Chen-Wei PanHua Zhong
Jul 7, 2007·Journal of Biomedical Optics·Gladimir V G Baranoski, Michael W Y Lam
Oct 2, 2020·International Journal of Molecular Sciences·Laurien E HoutzagersMartine J Jager
May 14, 2020·Current Eye Research·Dan-Ning HuJodi Sassoon
Sep 25, 2020·BMC Ophthalmology·Chen-Wei PanHua Zhong
Jan 11, 2014·Ophthalmology·Elizabeth SidharthaChing-Yu Cheng
Feb 17, 2000·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·T D LenartS R Lambert
Jan 20, 2007·American Journal of Human Genetics·David L DuffyRichard A Sturm
Feb 7, 2008·American Journal of Human Genetics·Manfred KayserCornelia M van Duijn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transactions of the American Ophthalmological Society
Daniel M AlbertJoel Gleiser
Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
Zhuang-Qun YangTie-Liang Zhang
Transactions of the Ophthalmological Societies of the United Kingdom
A C McCartneyD J Spalton
Current Opinion in Ophthalmology
I GriersonN Pfeiffer
© 2021 Meta ULC. All rights reserved