Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling

The Journal of Investigative Dermatology
Robert W RedmondHensin Tsao

Abstract

Long-wave UVA is the major component of terrestrial UV radiation and is also the predominant constituent of indoor sunlamps, both of which have been shown to increase cutaneous melanoma risk. Using a two-chamber model, we show that UVA-exposed target cells induce intercellular oxidative signaling to non-irradiated bystander cells. This UVA-mediated bystander stress is observed between all three cutaneous cell types (i.e., keratinocytes, melanocytes, and fibroblasts). Significantly, melanocytes appear to be more resistant to direct UVA effects compared with keratinocytes and fibroblasts, although melanocytes are also more susceptible to bystander oxidative signaling. The extensive intercellular flux of oxidative species has not been previously appreciated and could possibly contribute to the observed cancer risk associated with prolonged UVA exposure.

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Citations

Oct 21, 2014·Photochemistry and Photobiology·Jean CadetJean-Luc Ravanat
Feb 7, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jean Cadet, Thierry Douki
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Jul 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hawasatu DumbuyaElena Oancea
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Jun 5, 2021·Mutation Research. Reviews in Mutation Research·Sharmi MukherjeeAnindita Chakraborty

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Methods Mentioned

BETA
flow
Assay
confocal microscopy
electrophoresis

Software Mentioned

Image J

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