PMID: 2504021Jul 1, 1989Paper

Melanocytes in vestibular dark cell areas in human fetuses

Acta Oto-laryngologica
Y IgarashiI Takahashi

Abstract

Melanocytes in human vestibular dark cell areas were observed to have round or spindle-shaped cell bodies with several processes. They were located below the basement membrane but the melanocyte processes were found in the dark cell epithelial layer closely adjacent to the dark cell processes or bodies without any separation from the basement membrane. Submicroscopic observations revealed melanin pigment in various stages of accumulation on the tyrosinase filaments in melanosomes. Three-dimensional stereoscopic observations clearly revealed the morphological characteristics of tyrosinase filaments, their helicoidal structure and some variations. Mature melanin granules developed from premelanosomes as the melanin pigments were gradually deposited onto the filaments. Through this progress of pigment accumulation, the melanosomes became darker. In the four mid-term fetuses used in the present investigation, few differences were seen in the mode of melanin deposition on the tyrosinase filaments. In view of the close spatial arrangement and contact of the melanocytes with the dark cells, it seems plausible that the melanocytes play some role in vestibular metabolism via the dark cells.

References

Jul 1, 1977·Acta Oto-laryngologica·D A Hilding, R D Ginzberg
Jan 1, 1989·Acta Oto-laryngologica·Y Igarashi
Sep 1, 1974·The Annals of Otology, Rhinology, and Laryngology·K A LaFerriereL G Johnsson
Jun 1, 1969·The Annals of Otology, Rhinology, and Laryngology·R S Kimura
Jul 1, 1982·Ear and Hearing·S R GarberC J Witkop
Jul 1, 1982·Ear and Hearing·D R Cunningham, M L Norris
Apr 1, 1980·International Journal of Pediatric Otorhinolaryngology·Y Igarashi, T Ishii
Aug 1, 1980·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·Y Igarashi
Sep 1, 1964·The Annals of Otology, Rhinology, and Laryngology·G F DOHLMAN

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Citations

Feb 24, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Carol LiYuri Agrawal
Jan 1, 1995·Acta Oto-laryngologica. Supplementum·M MasudaY Hosoda
Oct 20, 2020·Developmental Neurobiology·Edward S A van BeelenPeter Paul G van Benthem
Jun 17, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A L Kuntz, E C Oesterle

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