Abstract
Solid pseudopapillary tumor of the pancreas (SPT) is an uncommon neoplasm of low malignant potential, generally occurring in young women. The tumor is indolent, usually with long survival, even in the presence of extension into adjacent organs and metastases. Pathological features include solid, cellular, and cystic regions and degenerative pseudopapillae formation. Despite its distinctive morphology and cytological features, the cell lineage of this entity is unclear. Here we report a case of solid pseudopapillary tumor in a 48-year-old man with 10-year follow-up in which melanin pigment was found within the tumor cells. The tumor cells stained positive not only for melanocytic markers including S-100, HMB-45, and Fontana, but also other well-established markers for this kind of neoplasm such as alpha-antitrypsin (Alpha-AT), anti-alpha-chymotrypsin (AACT), NSE, CD10, cyclin D1, and beta-catenin. Electron microscopy confirmed the formation of premelanosomes and melanosome granules in the tumor cells. To our knowledge, this is the first report in which melanosomes were produced by SPT. Because melanocytes are derived from neurocrest, we hypothesize that the histogenesis of SPT is of neurocrest origin. This phenomenon may also be...Continue Reading
Citations
Feb 16, 2010·Langenbeck's Archives of Surgery·László RomicsViktória Ruszinkó
Dec 25, 2012·Medical Oncology·Hai-Xia LiSabin Subedi
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Nam Q NguyenAndrew V Biankin
May 6, 2005·Pathology International·Ondrej DaumMichal Michal
Feb 22, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Vinayata ManuballaMitchell S Cappell
Feb 28, 2014·CytoJournal·Sule CanberkFatih Gulsen
Jul 1, 2015·Pathology·Hyun Hee ChuWoo Sung Moon
Dec 13, 2006·Journal of Pediatric Surgery·Seung Hoon ChoiSuk Koo Lee
Oct 2, 2007·Histopathology·F Campbell, B Azadeh
Jun 13, 2012·Journal of Surgical Oncology·Jinhua YeChenghong Peng
Oct 22, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·S KoljenovićM A den Bakker
Aug 19, 2006·Experimental and Molecular Pathology·Nathash KallichandaSamuel W French
Jun 3, 2016·Middle East Journal of Digestive Diseases·Babak MirminachiAkram Pourshams
Jan 22, 2017·Digestive Diseases and Sciences·Anas GremidaDenis McCarthy
Sep 13, 2006·Journal of Surgical Oncology·Seong Min KimSeung Hoon Choi
Sep 27, 2006·The American Journal of Surgical Pathology·Jorge Albores-SaavedraSeth J Bilello
Nov 24, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xiuli LiuNirag Jhala
Jan 2, 2007·The American Journal of Surgical Pathology·Karen W Simpson, Jorge Albores-Saavedra
Apr 23, 2008·Magyar sebészet·Nóra HajdúAttila Oláh
Feb 28, 2009·Pancreas·Chang Moo KangWoo Jung Lee
Feb 13, 2007·International Journal of Cancer. Journal International Du Cancer·Mabruk ErhumaAstrid Kehlen
Jan 21, 2020·Archives of Pathology & Laboratory Medicine·Stefano La Rosa, Massimo Bongiovanni
Apr 18, 2020·BMC Surgery·Yanwen JinNansheng Cheng
Jun 19, 2019·Pathology Oncology Research : POR·Attila Zalatnai, Viktória Kis-Orha
May 4, 2021·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Sabine KerstingMonika Silvia Janot-Matuschek
Aug 7, 2021·Frontiers in Medicine·Nianting TongZhanyu Zhou