Melanocytomas of the optic nerve and uvea

International Ophthalmology Clinics
J J Khadem, J J Weiter

Abstract

Melanocytomas are an example of changing attitudes toward clinical management of intraocular tumors. They also might exemplify the power of pathological examination and follow-up in patient care and treatment. Prior to the observations of Zimmerman [10], most patients with melanocytomas underwent enucleation. Today, these patients are followed up conservatively and continue to enjoy vision. Melanocytomas are fairly uncommon tumors found more often in blacks and hyperpigmented individuals than in whites. Women are slightly more likely to have this tumor than are men. Melanocytomas are uniformly densely hyperpigmented lesions found on the optic nerve, choroid, ciliary body, and iris and are benign, stationary tumors that seldom cause symptoms or secondary complications. In patients with papillary melanocytomas, the most common visual disturbance is enlargement of the blind spot. With larger tumors, an afferent pupillary defect may be noted. Ciliary body and iris tumors may cause secondary anterior segment complications such as glaucoma, hyphema, or ectopia. Dispersion of pigment by melanocytomas is common and should not necessarily be interpreted as a sign of malignant transformation. Ancillary tests such as fluorescein angiograp...Continue Reading

Citations

Nov 12, 2003·Survey of Ophthalmology·Flavio A Marigo, Paul T Finger
Jul 15, 2015·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Syed Shoeb AhmadShuaibah Abdul Ghani

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