Melanoma as a second malignant neoplasm after childhood cancer

American Journal of Surgery
C A CorpronR J Andrassy

Abstract

As more children survive childhood cancers, the population at risk for second malignant tumors increases. The development of melanoma as a second malignant tumor is not well described. The M.D. Anderson Cancer Center's 50-year experience with patients who developed melanoma after treatment of a childhood cancer was retrospectively reviewed. One hundred seventy-two patients with a second malignancy were identified; 11 patients had melanoma as a second malignancy. The most common first malignancies were Hodgkin's disease, brain tumors, and retinoblastomas. Melanoma developed in an irradiated field in 4 patients. Six patients had lymphatic or distant metastasis at diagnosis. Five of 11 patients died of melanoma. Factors contributing to melanoma as a second malignancy may include genetic factors and the effects of chemotherapy and radiation. Survivors of childhood malignancy should be considered at risk for developing melanoma, and suspicious pigmented lesions should be carefully evaluated.

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Citations

Oct 31, 2003·Journal of the American College of Surgeons·Steven D Miller, Richard J Andrassy
Feb 27, 2001·European Journal of Radiology·J MoppettA W Duncan
Jun 12, 2001·European Journal of Radiology·J MoppettA W Duncan
Dec 10, 1999·Seminars in Oncology Nursing·K Ruble, K P Kelly
Oct 15, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S GuérinF de Vathaire
Apr 28, 2007·Pediatric Dermatology·Jason C ReutterPamela A Groben
Apr 27, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sally-Ann Clarke, Christine Eiser
Aug 18, 2012·The Australasian Journal of Dermatology·Stephanie Jane Arnold, Jonathan Bowling
Jun 9, 2015·Clinical Nuclear Medicine·Shamima AhmedBruce Mahoney
Mar 4, 2011·Archives of Pathology & Laboratory Medicine·Sabela ParadelaVictor G Prieto

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