Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential

The Journal of Investigative Dermatology
Erika M YazawaCharles J Dimitroff

Abstract

Galectin-1 (Gal-1)-binding to Gal-1 ligands on immune and endothelial cells can influence melanoma development through dampening antitumor immune responses and promoting angiogenesis. However, whether Gal-1 ligands are functionally expressed on melanoma cells to help control intrinsic malignant features remains poorly understood. Here, we analyzed expression, identity, and function of Gal-1 ligands in melanoma progression. Immunofluorescent analysis of benign and malignant human melanocytic neoplasms revealed that Gal-1 ligands were abundant in severely dysplastic nevi, as well as in primary and metastatic melanomas. Biochemical assessments indicated that melanoma cell adhesion molecule (MCAM) was a major Gal-1 ligand on melanoma cells that was largely dependent on its N-glycans. Other melanoma cell Gal-1 ligand activity conferred by O-glycans was negatively regulated by α2,6 sialyltransferase ST6GalNAc2. In Gal-1-deficient mice, MCAM-silenced (MCAM(KD)) or ST6GalNAc2-overexpressing (ST6(O/E)) melanoma cells exhibited slower growth rates, underscoring a key role for melanoma cell Gal-1 ligands and host Gal-1 in melanoma growth. Further analysis of MCAM(KD) or ST6(O/E) melanoma cells in cell migration assays indicated that Gal-1...Continue Reading

References

Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M LehmannJ P Johnson
Dec 14, 1995·Nature·N L PerilloL G Baum
Sep 29, 1995·The Journal of Biological Chemistry·R D WhitakerC A Batt
Aug 1, 1996·Glycoconjugate Journal·B WoynarowskaR J Bernacki
Jan 9, 2001·International Journal of Cancer. Journal International Du Cancer·N TinariF T Liu
Oct 22, 2003·The Journal of Experimental Medicine·Louise A KoopmanJack L Strominger
Sep 13, 2005·Human Pathology·Dara L AisnerDavid M Berman
Jul 15, 2006·Glycobiology·Isabelle CambyRobert Kiss
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Victor L J L ThijssenArjan W Griffioen
Nov 18, 2006·Blood·Marina I GarínRobert I Lechler
Nov 21, 2007·Nature Medicine·Sandra M BloisPetra C Arck
Jan 19, 2008·The American Journal of Pathology·Victor L ThijssenArjan W Griffioen
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hernan D KopcowJack L Strominger
Dec 24, 2008·The Journal of Biological Chemistry·Sean R StowellRichard D Cummings
Nov 19, 2009·The Journal of Biological Chemistry·Lesley A EarlLinda G Baum
Jul 22, 2010·Cancer Research·Victor L ThijssenArjan W Griffioen
Sep 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Filiberto Cedeno-LaurentCharles J Dimitroff
Jan 8, 2011·Cancer Research·Natasha Y FrankMarkus H Frank
Apr 16, 2011·The Journal of Biological Chemistry·Steven R BarthelCharles J Dimitroff
Dec 14, 2011·The Journal of Investigative Dermatology·Filiberto Cedeno-LaurentCharles J Dimitroff
Jan 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Qiqun ZengXiyun Yan
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Filiberto Cedeno-LaurentCharles J Dimitroff
Mar 6, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ha-Jeong KimByoung-Gie Kim
May 25, 2012·The Journal of Investigative Dermatology·Véronique MathieuOlivier Feron
Jun 8, 2012·Pigment Cell & Melanoma Research·Russell R BraeuerMenashe Bar-Eli
Jun 22, 2012·Blood·Tianxia JiangXiyun Yan
Dec 12, 2012·The Journal of Biological Chemistry·Nathalie JouveAurélie S Leroyer
Dec 26, 2012·Cancer Letters·Zhaoqing Wang, Xiyun Yan

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Citations

Mar 28, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Robert SacksteinSteven R Barthel
Jun 19, 2018·Cancers·Emily Rodrigues, Matthew S Macauley
Jun 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sheue-Fen TzengPei-Wen Hsiao
Feb 26, 2019·The American Journal of Dermatopathology·Enrique ArciniegasMarina Chopite
Jan 17, 2016·Chembiochem : a European Journal of Chemical Biology·Sang-Hyun SonOsamu Kanie
Feb 26, 2016·Journal of Translational Medicine·Federica FelicettiAlessandra Carè
Aug 24, 2018·Nature Communications·Jenna Geddes SweeneyCharles J Dimitroff
Jun 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Charles J Dimitroff
Aug 13, 2020·Signal Transduction and Targeted Therapy·Zhaoqing WangXiyun Yan
Jun 25, 2017·Cancer Research·Satyendra C TripathiSamir M Hanash
Aug 1, 2015·Cancer Research·Charles J Dimitroff
May 20, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alejandro J CagnoniGabriel A Rabinovich
May 23, 2021·Journal of Cell Communication and Signaling·Alessandra TotiPaolo Cirri

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