PMID: 15383566Sep 24, 2004Paper

Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kappa B activation and suppresses apoptosis induced by TNF

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sita AggarwalBharat B Aggarwal

Abstract

Melanoma differentiation-associated gene-7 (mda-7), also referred to as IL-24, is a novel growth regulatory cytokine that has been shown to regulate the immune system by inducing the expression of inflammatory cytokines, such as TNF, IL-1, and IL-6. Whether the induction of these cytokines by MDA-7 is mediated through activation of NF-kappaB or whether it regulates cytokine signaling is not known. In the present report we investigated the effect of MDA-7 on NF-kappaB activation and on TNF-induced NF-kappaB activation and apoptosis in human embryonic kidney 293 cells. Stable or transient transfection with mda-7 into 293 cells failed to activate NF-kappaB. However, TNF-induced NF-kappaB activation was significantly enhanced in mda-7-transfected cells, as indicated by DNA binding, p65 translocation, and NF-kappaB-dependent reporter gene expression. Mda-7 transfection also potentiated NF-kappaB reporter activation induced by TNF receptor-associated death domain and TNF receptor-associated factor-2. Cytoplasmic MDA-7 with deleted signal sequence was as effective as full-length MDA-7 in potentiating TNF-induced NF-kappaB reporter activity. Secretion of MDA-7 was not required for the potentiation of TNF-induced NF-kappaB activation. T...Continue Reading

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J JouanneauJ P Thiery
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KumarB R Williams
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·H JiangP B Fisher
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z Z SuP B Fisher
Jul 20, 1999·Molecular and Cellular Biology·D C GuttridgeA S Baldwin
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Jul 25, 2000·Methods in Enzymology·M M ChaturvediB B Aggarwal
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K MannaB B Aggarwal
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K MannaB B Aggarwal
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·Z SuP B Fisher
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L DumoutierJ C Renauld
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·S EkmekciogluE A Grimm
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva G CaudellElizabeth A Grimm
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Devanand SarkarPaul B Fisher
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuan-Chun LiaoMing-Shi Chang
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mónica B FrungieriArtur Mayerhofer
Nov 28, 2002·Gastroenterology·Florian R GretenRoland M Schmid
Dec 18, 2002·Cytokine & Growth Factor Reviews·Moira SauanePaul B Fisher
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Mar 10, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kerry A SiegerSunil Chada
May 4, 2004·International Immunopharmacology·Sunil ChadaAbner M Mhashilkar

❮ Previous
Next ❯

Citations

May 10, 2020·Zygote : the Biology of Gametes and Early Embryos·José R V SilvaAnderson W B Silva
Jan 26, 2005·Immunology·Mai Wang, Peng Liang
Apr 13, 2011·International Journal of Cancer. Journal International Du Cancer·S AggarwalW Hansel
Jul 11, 2006·Expert Review of Molecular Diagnostics·Bodour SalhiaMichael E Berens
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoh MatsumiyaDiana M Stafforini
Sep 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Yolande CordeauxGordon C S Smith
Oct 16, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giang Huong NguyenCurtis C Harris
Nov 22, 2005·Molecular and Cellular Endocrinology·Christine Glidewell-KenneyJ Larry Jameson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis