Melanoma Outcomes in Transplant Recipients With Pretransplant Melanoma.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Sarah T ArronEric A Engels

Abstract

There are limited data on outcomes in transplant recipients with a history of pretransplant melanoma. To determine whether pretransplant melanoma is associated with differences in survival or posttransplant melanoma risk. We evaluated the outcomes of 185,039 US transplant recipients from the Transplant Cancer Match Study. We also evaluated the impact of transplantation on 141,441 patients with melanoma identified in cancer registries. There were 336 transplant recipients (0.18%) with pretransplant melanoma; they had increased risk of melanoma-specific mortality (hazard ratio [HR], 27; 95% confidence interval [CI], 11-64, p < .0001), overall mortality (HR, 1.3; 95% CI, 1.0-1.5, p = .02), and incident melanoma (HR, 5.4; 95% CI, 2.9-9.8, p < .0001) after transplant, compared with recipients without pretransplant melanoma. The 10-year absolute risk difference was 2.97% for melanoma-specific mortality, 3.68% for incident melanoma, and 14.32% for overall mortality. Among the 141,441 patients with melanoma in the general population, 68 (0.05%) subsequently received a transplant. Transplantation increased melanoma-specific mortality, but not significantly (HR, 1.7; 95% CI, 0.61-4.5, p = .32). Pretransplant melanoma is associated with i...Continue Reading

References

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Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Clark C OtleyStuart J Salasche
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R N MatinUNKNOWN Skin Care in Organ Transplant Patients, Europe (SCOPE) group
Nov 3, 2011·JAMA : the Journal of the American Medical Association·Eric A EngelsMonica Lin
Mar 22, 2014·Cancer Biology & Therapy·Martina SanlorenzoSusanna Ortiz-Urda

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Citations

May 31, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Mittal, O R Colegio
Jun 27, 2018·Melanoma Research·Charles J PuzaPaul J Mosca
Aug 7, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Wai H LimGermaine Wong
Sep 26, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·David P Al-AdraKymberly D Watt
Nov 2, 2020·Actas dermo-sifiliográficas·S Esteban Terradillos, J Gardeazabal García
Nov 17, 2020·Actas dermo-sifiliográficas·C González-CruzV García-Patos Briones
Sep 15, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Marion PatrasEmilie Ducroux

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