Melanoma vaccines: clinical status and immune endpoints

Melanoma Research
Deena M MaurerLazar Vujanovic

Abstract

It has been known for decades that the immune system can be spontaneously activated against melanoma. The presence of tumor infiltrating lymphocytes in tumor deposits is a positive prognostic factor. Cancer vaccination includes approaches to generate, amplify, or skew antitumor immunity. To accomplish this goal, tested approaches involve administration of tumor antigens, antigen presenting cells or other immune modulators, or direct modulation of the tumor. Because the success of checkpoint blockade can depend in part on an existing antitumor response, cancer vaccination may play an important role in future combination therapies. In this review, we discuss a variety of melanoma vaccine approaches and methods to determine the biological impact of vaccination.

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Citations

Feb 15, 2021·Seminars in Cancer Biology·Alexandre CorthayColin C Anderson
Feb 16, 2021·Frontiers in Oncology·Leona YamamotoKenneth Carl Anderson
Feb 25, 2021·Melanoma Research·Ferdy J LejeunePatrick A Riley
Mar 25, 2021·Hematology/oncology Clinics of North America·Alexandra M HaughDouglas B Johnson
Apr 28, 2021·Journal of Translational Medicine·Ottavia ClementeSalvatore Tafuto

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
exome sequencing
biopsies
flow cytometry
RNA-seq
biopsy

Clinical Trials Mentioned

NCT02385669
NCT02950766
NCT02897765
NCT03410901
NCT03153085

Software Mentioned

Epitope Discovery and Improvement System

Related Concepts

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Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.