PMID: 15249859Jul 14, 2004Paper

Melanoma with prominent pigment synthesis (animal-type melanoma): a case report with ultrastructural studies

The American Journal of Dermatopathology
Dmitry V KazakovMichal Michal

Abstract

Melanoma with prominent pigment synthesis or animal-type melanoma (ATM) is a very rare type of melanoma. Its histogenesis has not been elucidated and ultrastructural features have not been described in human beings. We present an additional case of ATM in a 28-year-old woman with positive sentinel node biopsy and provide the results of electron microscopic studies. Histopathologically, the skin lesion was composed of heavily pigmented neoplastic cells mostly arranged as large sheets, focally also in a nodular growth pattern. After bleaching, the neoplastic cells demonstrated round nuclei with 1 or rarely 2 conspicuous nucleoli and a prominent nuclear membrane and abundant, gray, slate-like cytoplasm. Some cells demonstrated round cytoplasmic inclusions. There was no nuclear pleomorphism, and only a few mitotic figures could be found after extensive search. Multiple areas of necrosis en masse of tumor cells were seen. The lymph node biopsy revealed a complete effacement of the lymph node architecture by the extensive proliferation of hyperpigmented cells in the parenchyma. Immunohistochemically, the same pattern of staining was seen on the bleached and unbleached slides both in the skin and in the lymph node. The neoplastic cell...Continue Reading

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Citations

Sep 28, 2007·Der Pathologe·H KutznerL Requena
Jul 11, 2009·The American Journal of Dermatopathology·Denisa KacerovskaDmitry V Kazakov
Feb 2, 2010·Journal of the American Academy of Dermatology·Sook Jung YunHoon Kook
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May 18, 2018·The American Journal of Dermatopathology·Jarish N CohenTimothy H McCalmont
Jan 24, 2020·The American Journal of Dermatopathology·Michele DonatiDmitry V Kazakov
Jan 10, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·S SestiniL Borgognoni

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