Melanopsin-mediated pupil function is impaired in Parkinson's disease

Scientific Reports
Daniel S JoyceAndrew J Zele

Abstract

Parkinson's disease (PD) is characterised by non-motor symptoms including sleep and circadian disruption. Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGC) transmit light signals to brain areas controlling circadian rhythms and the pupil light reflex. To determine if non-motor symptoms observed in PD are linked to ipRGC dysfunction, we evaluated melanopsin and rod/cone contributions to the pupil response in medicated participants with PD (n = 17) and controls (n = 12). Autonomic tone was evaluated by measuring pupillary unrest in darkness. In the PD group, there is evidence for an attenuated post-illumination pupil response (PIPR) amplitude and reduced pupil constriction amplitude, and PIPR amplitudes did not correlate with measures of sleep quality, retinal nerve fibre layer thickness, disease severity, or medication dosage. Both groups exhibited similar pupillary unrest. We show that melanopsin- and the rod/cone-photoreceptor contributions to the pupil control pathway are impaired in people with early-stage PD who have no clinically observable ophthalmic abnormalities. Given that ipRGCs project to brain targets involved in arousal, sleep and circadian rhythms, ipRGC dysfunction may underpin som...Continue Reading

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Citations

Nov 28, 2018·Investigative Ophthalmology & Visual Science·Harrison McAdamsGeoffrey K Aguirre
Dec 21, 2019·Journal of Sleep Research·Daniel S JoycePrakash Adhikari
Mar 12, 2019·Frontiers in Neurology·Carina KelbschBarbara J Wilhelm
Oct 23, 2019·Translational Vision Science & Technology·Prakash AdhikariAndrew J Zele
Oct 6, 2020·Neuro-ophthalmology·Hasan KızıltoprakPelin Yilmazbas
Dec 26, 2018·Frontiers in Neurology·Chiara La MorgiaMichele Carbonelli
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Apr 30, 2019·Frontiers in Neurology·Pratik S ChouguleDan Milea
Sep 29, 2020·Journal of Parkinson's Disease·Beatrix FeiglAndrew J Zele
Sep 22, 2020·Chest·Annie C LajoieMarta Kaminska
Jan 14, 2021·Scientific Reports·Babak Zandi, Tran Quoc Khanh
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Apr 13, 2021·Frontiers in Neurology·Ludovic S Mure
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Jul 16, 2021·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Samir UpretyPrakash Adhikari
Aug 17, 2021·Frontiers in Neuroscience·Matthew BernardinisMandar S Jog

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