Melanopsin-mediated pupil function is impaired in Parkinson's disease

Scientific Reports
Daniel S JoyceAndrew J Zele


Parkinson's disease (PD) is characterised by non-motor symptoms including sleep and circadian disruption. Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGC) transmit light signals to brain areas controlling circadian rhythms and the pupil light reflex. To determine if non-motor symptoms observed in PD are linked to ipRGC dysfunction, we evaluated melanopsin and rod/cone contributions to the pupil response in medicated participants with PD (n = 17) and controls (n = 12). Autonomic tone was evaluated by measuring pupillary unrest in darkness. In the PD group, there is evidence for an attenuated post-illumination pupil response (PIPR) amplitude and reduced pupil constriction amplitude, and PIPR amplitudes did not correlate with measures of sleep quality, retinal nerve fibre layer thickness, disease severity, or medication dosage. Both groups exhibited similar pupillary unrest. We show that melanopsin- and the rod/cone-photoreceptor contributions to the pupil control pathway are impaired in people with early-stage PD who have no clinically observable ophthalmic abnormalities. Given that ipRGCs project to brain targets involved in arousal, sleep and circadian rhythms, ipRGC dysfunction may underpin som...Continue Reading


Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·G MicieliG Nappi
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jun 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·L J FindleyG M Halmagyi
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·I ProvencioM D Rollag
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J S Richman, J R Moorman
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S M Pincus
Nov 20, 2001·Nature Neuroscience·J J GooleyC B Saper
Feb 9, 2002·Science·David M BersonMotoharu Takao
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia RamakerBob Johannes Van Hilten
Apr 15, 2003·The Journal of Comparative Neurology·Michael A BelenkyGary E Pickard
Sep 3, 2004·Vision Research·Rivka InzelbergAvinoam Ophir
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Martine VisserJacobus J Van Hilten
Oct 27, 2004·Neurologic Clinics·Richard B Dewey
Apr 27, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Rodger J ElbleSuzanne Elble
Feb 21, 2006·Lancet Neurology·K Ray ChaudhuriUNKNOWN National Institute for Clinical Excellence
Jun 1, 2006·The Journal of Comparative Neurology·Samer HattarDavid M Berson
Feb 27, 2007·Vision Research·Paul D R GamlinDennis M Dacey
Mar 17, 2007·Experimental Neurology·Anthony A VuglerPeter J Coffey
Aug 31, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Jan van de Kraats, Dirk van Norren
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dao-Qi ZhangDouglas G McMahon
Dec 3, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Vasilios StergiouAnna Karlovasitou
Dec 4, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M A ReyesM Merello
Jan 2, 2009·Nature·Michael Tri H DoKing-Wai Yau
May 6, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·D F FotiouA Karlovasitou
Jun 10, 2009·Archives of Ophthalmology·Mohammedyusuf E HajeeIvan G Bodis-Wollner
Jun 25, 2009·PloS One·Ludovic S MureHoward M Cooper
Dec 17, 2009·Investigative Ophthalmology & Visual Science·Laxmikanth KankipatiPaul D Gamlin
Jun 19, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Emma L MarkwellAndrew J Zele
Jun 25, 2010·Neurology·G K KerrP A Silburn
Sep 8, 2010·Parkinsonism & Related Disorders·S DonovanD K Simon
Dec 1, 2010·Parkinsonism & Related Disorders·Samay JainJ Timothy Greenamyre
Mar 23, 2011·PloS One·Andrew J ZeleEmma L Markwell
Apr 19, 2011·Investigative Ophthalmology & Visual Science·Beatrix FeiglAndrew J Zele
Jul 12, 2011·Investigative Ophthalmology & Visual Science·Jason C ParkDonald C Hood
Feb 7, 2012·The European Journal of Neuroscience·Matthew J Van HookDavid M Berson

❮ Previous
Next ❯


Nov 28, 2018·Investigative Ophthalmology & Visual Science·Harrison McAdamsGeoffrey K Aguirre
Dec 21, 2019·Journal of Sleep Research·Daniel S JoycePrakash Adhikari
Mar 12, 2019·Frontiers in Neurology·Carina KelbschBarbara J Wilhelm
Oct 23, 2019·Translational Vision Science & Technology·Prakash AdhikariAndrew J Zele
Oct 6, 2020·Neuro-ophthalmology·Hasan KızıltoprakPelin Yilmazbas
Dec 26, 2018·Frontiers in Neurology·Chiara La MorgiaMichele Carbonelli
Jul 17, 2019·Investigative Ophthalmology & Visual Science·Gloria L Duque-ChicaDora F Ventura
Jul 3, 2019·International Journal of Molecular Sciences·Pedro LaxNicolás Cuenca
Apr 30, 2019·Frontiers in Neurology·Pratik S ChouguleDan Milea
Sep 29, 2020·Journal of Parkinson's Disease·Beatrix FeiglAndrew J Zele
Sep 22, 2020·Chest·Annie C LajoieMarta Kaminska
Jan 14, 2021·Scientific Reports·Babak Zandi, Tran Quoc Khanh
Apr 8, 2021·Journal of Biomedical Informatics·Hedenir Monteiro Pinheiro, Ronaldo Martins da Costa
Apr 13, 2021·Frontiers in Neurology·Ludovic S Mure
May 5, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bruce I GaynesTing Xiao
Jun 8, 2021·Frontiers in Neurology·Ungsoo Samuel KimPatrick Yu-Wai-Man
Jul 6, 2021·Frontiers in Neuroscience·Babak ZandiTran Quoc Khanh
Jul 16, 2021·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Samir UpretyPrakash Adhikari
Aug 17, 2021·Frontiers in Neuroscience·Matthew BernardinisMandar S Jog

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.