Melanotic ependymoma and subependymoma

The American Journal of Surgical Pathology
Marc K RosenblumG N Budzilovich

Abstract

We report two examples of melanin production by human gliomas. One was a grossly pigmented, well-differentiated ependymoma resected from the left frontoparietal region of a 13-year-old girl. The patient received radiotherapy and was free of tumor 12 years after operation. The second example was a pigmented subependymoma incidentally discovered at the autopsy of a 52-year-old man. Neoplastic cells containing an intracytoplasmic pigment satisfying histochemical criteria for melanin were present in both cases. Electron microscopic study of the melanotic ependymoma revealed electron-dense granules in the cytoplasm of cells forming rosettes. Premelanosomes were not detected. While the mechanism of melanogenesis in these cases is obscure, they support the potential of glial derivatives to produce melanin and indicate that melanogenesis in such neoplasms may have no adverse prognostic import.

Citations

Jan 1, 1992·Diagnostic Cytopathology·A E Walts
Sep 15, 2004·Acta Neuropathologica·Bård Kronen KrossnesSverre Jarl Mørk
Jul 21, 2007·Acta Neuropathologica·Mohanpal S DulaiNorman L Lehman
Sep 30, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Giuseppe M V BarbagalloSalvatore Lanzafame
Sep 9, 1999·The American Journal of Surgical Pathology·T H NgJ S Compton
Mar 19, 2008·The American Journal of Surgical Pathology·Fausto J RodriguezPeter C Burger
Jun 11, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yesim ErtanTaner Akalin
Jul 23, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Manila AntonelliFelice Giangaspero
Jun 25, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ji XiongYin Wang
Aug 29, 2003·Neurosurgery·George M KleinmanDouglas C Miller
Jul 2, 2008·Journal of Neurosurgery. Spine·Eric M HornCurtis A Dickman
Feb 1, 2013·Journal of Radiology Case Reports·Ahmed K Abdel-AalAsim Bag
Oct 4, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mena G KerolusRichard W Byrne
Mar 18, 2004·Neurosurgery Clinics of North America·James S Waldron, Tarik Tihan
Sep 29, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Dorel ArseneLeon Danaila
Jul 28, 2011·Virchows Archiv : an International Journal of Pathology·Marco GessiTorsten Pietsch
Mar 10, 2004·Journal of Cutaneous Pathology·Klaus J Busam, Christina M Lohmann
Jan 1, 1994·Ultrastructural Pathology·A SaraB Mackay
Jan 1, 1996·Ultrastructural Pathology·G W MierauE N Orsini
Apr 1, 2013·Journal of Investigative Medicine High Impact Case Reports·Brandon A MillerNelson M Oyesiku
Nov 1, 1992·Ultrastructural Pathology·J L Twiss, D S Horoupian
May 27, 2020·International Journal of Surgical Pathology·Ankit MalhotraSathwik Shetty
Jun 26, 2003·Archives of Pathology & Laboratory Medicine·Alexander Chak Lam ChanFung Ching Cheung
May 24, 2001·Archives of Pathology & Laboratory Medicine·M C SharmaC Sarkar
Aug 25, 2001·Archives of Pathology & Laboratory Medicine·C E FullerR Schelper
Mar 18, 2004·Neurosurgery Clinics of North America·Aaron S DumontMark E Shaffrey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.