Melanotic Neuroectodermal Tumor of Infancy: A Clinicopathological and BRAF V600E Mutation Study of 11 Cases.

Frontiers in Oncology
Rong-Hui XiaJiang Li

Abstract

To investigate the clinicopathological features and BRAF V600E mutation of melanotic neuroectodermal tumor of infancy (MNTI). Eleven cases of MNTI diagnosed at the Department of Oral Pathology were collected. Clinicopathological characteristics were obtained from the medical records. Immunostaining was performed by immunohistochemistry (IHC). Amplification-Refractory Mutation System-qPCR (ARMS-qPCR) and Sanger Sequencing were used to detect BRAF V600E mutation. Of the 11 cases, 3 cases were female and 8 cases were male. The mean age of the first symptoms was 3.2 months (range: 1 to 6 months). Ten cases (90.9%) located in maxilla but only one (9.1%) in mandible. Most of the cases demonstrated well-defined mass with lytic bone destruction and tooth germ affecting radiologically. Histologically, MNTI was consisted of large polygonal melanin-producing epithelioid cells and small round neuroblast-like cells which arranged in irregular alveolar, tubuloglandular and fissured architecture. The epithelioid cells expressed Vim, Pan-CK, NSE and HMB45, while the smalls cells expressed Syn, NSE and scattered Vim. Most cases showed low Ki-67 index (range: <1% to 50%). None of the MNTI cases showed BRAF V600E mutation. Most cases were treated...Continue Reading

References

Aug 27, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·M KhoddamiP Thorner
Jul 27, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·A W BarrettP M Speight
Jan 9, 2003·Medical and Pediatric Oncology·Willi WoessmannAlfred Reiter
Mar 1, 1960·The British Journal of Surgery·T C HENRY, M BODIAN
Jan 1, 1951·Cancer·H MARTIN, F W FOOTE
Aug 4, 2004·Annals of Diagnostic Pathology·Márcia Gaiger de OliveiraManoel Sant'Ana Filho
Aug 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Birgit Kruse-LöslerJohannes Kleinheinz
Dec 20, 2007·Journal of Pediatric Hematology/oncology·Ic Sun ChoiTai Ju Hwang
Jul 8, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Johannus NevenMatthais A W Merkx
May 6, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Saleh RachidiTerry A Day
Apr 25, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Christopher MarounRoger V Moukarbel
May 4, 2017·Nature·Nicholas K HaywardGraham J Mann
Dec 25, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Audrey MoreauNatacha Kadlub
May 17, 2018·Einstein·Hellen Bandeira de Pontes SantosPollianna Muniz Alves
Sep 2, 2018·International Journal of Oral and Maxillofacial Surgery·B R Chrcanovic, R S Gomez
Nov 9, 2018·Archives of Pathology & Laboratory Medicine·Brian S SolesAmer Heider
Mar 16, 2019·International Journal of Oral and Maxillofacial Surgery·A J RickartC Mills
Apr 11, 2019·Journal of Oral and Maxillofacial Pathology : JOMFP·Preeti SharmaAshish Kumar Mandal
Aug 18, 2020·European Journal of Medicinal Chemistry·Jaydeepsinh Chavda, Hardik Bhatt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Birgit Kruse-LöslerJohannes Kleinheinz
Diagnostic Cytopathology
Sheila J AdadDenise B R Rodrigues
International Journal of Surgery Case Reports
Shady A MoussaFahmy A Mobarak
© 2021 Meta ULC. All rights reserved