PMID: 9556097Apr 29, 1998Paper

Melatonin--the key to the gate of sleep

Annals of Medicine
T ShochatP Lavie

Abstract

This article reviews the evidence that melatonin, a hormone produced by the pineal gland during the dark hours, plays a major role in the regulation of the sleep-wake cycle. In recent years, our laboratory has been involved in a large-scale project aimed at investigating the role of endogenous melatonin in sleep-wake regulation and the effects of nonpharmacological levels of melatonin on sleep. Based on our finding on the precise coupling between the endogenous nocturnal increase in melatonin secretion and the opening of the nocturnal sleep gate, we propose that the role of melatonin in the induction of sleep does not involve the active induction of sleep, but is rather mediated by an inhibition of a wakefulness-producing mechanism in the central nervous system. Our studies also suggest that exogenously administered melatonin may be beneficial in certain types of insomnia that are related to disturbances in the normal secretion of the hormone.

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Citations

Oct 12, 2000·The New England Journal of Medicine·J Arendt
Dec 26, 2001·The New England Journal of Medicine·P Lavie
Feb 27, 2013·Human Reproduction·N ShreeveY Cheong
Jul 9, 2009·International Clinical Psychopharmacology·Remy LuthringerLuc Staner
Dec 8, 2009·Neuroscience and Biobehavioral Reviews·Gena Glickman
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Jan 15, 2005·Sleep Medicine Reviews·Amnon BrzezinskiIan Ford
Jul 10, 2013·Annals of Medicine·Timo Partonen
Apr 21, 2017·Chronobiology International·Gabriela Melloni ZuculoLuciana Pinato
Aug 24, 2016·The Cochrane Database of Systematic Reviews·Tracy E SlangerThomas C Erren
Apr 28, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chiara PilottoMaurizio Mascarin
Jul 7, 2007·Journal of Pineal Research·Tali Gorfine, Nava Zisapel
May 7, 2014·World Journal of Hepatology·Kangsadarn BennukulVijittra Leardkamolkarn
Jan 10, 2021·Journal of Pineal Research·Sanseray da Silveira Cruz-MachadoLuciana Pinato
Jan 11, 2021·Clinical Breast Cancer·Martin ChartogneBaptiste Morel

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