Melatonin, a calpain inhibitor in the central nervous system: Current status and future perspectives

Journal of Cellular Physiology
Omid Reza TamtajiZatollah Asemi

Abstract

Dysregulation of neuronal Ca2+ and oxidative stress plays an important role in the activation of cysteine proteases including calpains and caspases that contribute to neuronal death. In neurodegenerative diseases, traumatic brain injury, stroke, and neuropathic pain calpain activities are markedly increased. Melatonin is a beneficial supplement in the treatment of central nervous system (CNS) disorders. Melatonin is a potent antioxidant and works as a free-radical scavenger to regulate a large number of molecular pathways, including oxidative stress, inflammation, apoptosis, and cell death under different pathological conditions. However, limited studies have evaluated the inhibitory effect of melatonin on calpains. This review summarizes the current knowledge related to the effects of melatonin on calpains in some of the common CNS disorders.

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Citations

May 14, 2019·Journal of Toxicology and Environmental Health. Part a·Chunyan YaoTongjian Cai
Aug 8, 2019·Cellular and Molecular Neurobiology·Omid Reza TamtajiZatollah Asemi
Jan 24, 2021·Immunologic Research·Yueqi ChenFang Liu
Feb 6, 2021·Biochimica Et Biophysica Acta. Proteins and Proteomics·Simone SpinozziIsabelle Richard
Dec 17, 2018·Chemico-biological Interactions·Evgenios AgathokleousEdward J Calabrese
Apr 21, 2021·Food & Function·Guo ChengXiangyu Sun

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