PMID: 11316323Apr 24, 2001Paper

Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats

Journal of Pineal Research
M HaraK Hirata

Abstract

In an attempt to define the role of the pineal secretory melatonin and an analogue, 6-hydroxymelatonin (6-OHM), in limiting oxidative stress, the present study investigated the cisplatin (CP)-induced alteration in the renal antioxidant system and nephroprotection with the two indolamines. Melatonin (5 mg/kg), 6-OHM (5 mg/kg), or an equal volume of saline were administered intraperitoneally (i.p.) to male Sprague Dawley rats 30 min prior to an i.p. injection of CP (7 mg/kg). After CP treatment, the animals each received indolamine or saline every day and were sacrificed 3 or 5 days later and plasma as well as kidney were collected. Both plasma creatinine and blood urea nitrogen increased significantly following CP administration alone; these values decreased significantly with melatonin co-treatment of CP-treated rats. In the kidney, CP decreased the levels of GSH (reduced glutathione)/GSSG (oxidized glutathione) ratio, an index directly related to oxidative stress. When animals were treated with melatonin, the reduction in the GSH/GSSG ratio was prevented. Treatment of CP-enhanced lipid peroxidation in the kidney was again prevented in animals treated with melatonin. The activity of the antioxidant enzyme, glutathione peroxidas...Continue Reading

Citations

Aug 17, 2006·Journal of Physiology and Biochemistry·J F López-OlmedaF J Sánchez-Vázquez
Apr 25, 2012·Archives of Toxicology·In-Chul LeeJong-Choon Kim
Sep 11, 2007·Bioscience Reports·Deepa S MaharajSanty Daya
Jul 26, 2002·Life Sciences·Göksel SenerBerrak C Yeğen
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohamed H Abdel-WahabAshraf B Abdel-Naim
Jul 1, 2009·Nature Reviews. Nephrology·Vaibhav SahniZiauddin Ahmed
Jan 15, 2013·Nutrition & Metabolism·Ulkan KilicKazim Sahin
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Upal Kanti MazumderSivakumar Thangavel
Jun 25, 2014·European Journal of Clinical Pharmacology·Atefeh JafariSimin Dashti-Khavidaki
Jun 2, 2011·International Journal of Alzheimer's Disease·Venkatramanujam SrinivasanDaniel P Cardinali
Aug 1, 2015·International Journal of Molecular Sciences·Aroha SánchezBeatriz Clares
Jan 12, 2011·Expert Opinion on Drug Safety·Victoria LinaresJosé L Domingo
Aug 30, 2011·Drug Development and Industrial Pharmacy·Osman CiftciIsmail Ozdemir
Nov 1, 2013·Drug and Chemical Toxicology·Ufuk ErenberkUlkan Kilic
Apr 17, 2012·Expert Opinion on Investigational Drugs·Emilio J Sanchez-BarceloRussel J Reiter
Oct 15, 2013·Archives of Medical Research·Recep BentliMustafa Sagir
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tuzz-Ying SongMing-Shiun Tsai
Jan 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martins EkorEbenezer O Farombi
Nov 26, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H MalekinejadN Mirzakhani
Sep 17, 2008·Parkinsonism & Related Disorders·Jeannine MaJohn Mitrofanis
Sep 10, 2005·Journal of Pineal Research·Korhan ErkanliKaan Kirali
Jul 31, 2003·Journal of Pineal Research·Hakan ParlakpinarAhmet Acet
Jun 20, 2003·Journal of Biochemical and Molecular Toxicology·Abdulhakeem A Al-MajedAdel M Mostafa
Jul 23, 2008·Experimental Dermatology·Tobias W FischerRalf Paus
Aug 8, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Hakan ParlakpinarCemil Colak
Jun 9, 2004·Life Sciences·Josefa LeonRussel J Reiter
Mar 15, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badreldin H Ali, Mansour S Al Moundhri
Jun 29, 2005·Bioorganic & Medicinal Chemistry·Upal K MazumderThangavel Sivakumar
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Eda Kucuktulu
Aug 28, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nae-Cherng YangTuzz-Ying Song
Oct 25, 2002·The Journal of Pharmacy and Pharmacology·Russel J ReiterSilvia Lopez-Burillo
Feb 19, 2015·Annals of Surgical Treatment and Research·Mustafa OzsoyMurat Tosun
Sep 21, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bidya Dhar SahuRamakrishna Sistla
Oct 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh ShakiNematollah Ahangar
Jun 9, 2017·Biology of Reproduction·Ricássio S BarberinoMaria Helena T Matos

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