Nov 14, 2019

Melatonin: A review of its potential functions and effects on neurological diseases

Revue neurologique
M GunataH A Acet

Abstract

The aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global Burden of Disease Study 2015, neurological diseases are the second most common cause of death and 16.8% of total deaths are caused by neurological diseases worldwide. Neurological disease deaths have risen 36% worldwide in 25 years. Melatonin is a neuroregulator hormone that has free radical scavenger, strong antioxidant, anti-inflammatory, and immunosuppressive actions. These major properties of melatonin can play an important role in the pathophysiological mechanisms of neurological diseases. In addition, melatonin is necessary for circadian rhythm. Studies have shown that melatonin levels are low in people with neurological diseases. Both preventive and therapeutic effects of melatonin are known for many diseases, including neurological diseases (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, epilepsy, headache, etc.). Based on all these reasons, clinical trials of melatonin were performed and successful results were declared. In this review, biological and chemical knowledge of melatonin, its e...Continue Reading

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Mentioned in this Paper

Study
Epilepsy
Brain
Antioxidants
Cessation of Life
Melatonin
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Persons
Free Radical Scavengers

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