Melatonin agonists and insomnia

Expert Review of Neurotherapeutics
Sally A FergusonDrew Dawson

Abstract

The ability of melatonin to shift biological rhythms is well known. As a result, melatonin has been used in the treatment of various circadian rhythm sleep disorders, such as advanced and delayed sleep phase disorders, jet lag and shiftwork disorder. The current evidence for melatonin being efficacious in the treatment of primary insomnia is less compelling. The development of agents that are selective for melatonin receptors provides opportunity to further elucidate the actions of melatonin and its receptors and to develop novel treatments for specific types of sleep disorders. The agonists reviewed here - ramelteon, tasimelteon and agomelatine - all appear to be efficacious in the treatment of circadian rhythm sleep disorders and some types of insomnia. However, further studies are required to understand the mechanisms of action, particularly for insomnia. Clinical application of the agonists requires a good understanding of their phase-dependent properties. Long-term effects of melatonin should be evaluated in large-scale, independent randomized controlled trials.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S T Inouye, H Kawamura
Oct 1, 1976·The American Journal of Psychiatry·J S CarmanF K Goodwin
May 11, 1991·Lancet·M DahlitzJ D Parkes
Jan 1, 1991·Journal of Biological Rhythms·R L SackL D Keith
May 1, 1986·Electroencephalography and Clinical Neurophysiology·P Lavie
Jan 1, 1989·Journal of Biological Rhythms·B Rusak
Aug 1, 1988·Clinical Endocrinology·J Arendt
Jan 1, 1988·Journal of Pineal Research·J R Redman, S M Armstrong
Dec 2, 1995·Lancet·R J Wurtman, I Zhdanova
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·S M ArmstrongJ R Redman
Sep 1, 1995·Sleep·I HaimovN Zisapel
Mar 1, 1996·Journal of Sleep Research·C M EllisJ D Parkes
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·L MartinetE Mocaer
Jan 1, 1996·Pharmacology & Therapeutics·D Dawson, S M Armstrong
Mar 1, 1996·Trends in Pharmacological Sciences·S M ReppertC Godson
Apr 1, 1997·The American Journal of Physiology·L GarciaP Sartor
Dec 24, 1997·Journal of Biological Rhythms·J R Redman
Dec 24, 1997·Journal of Biological Rhythms·J ArendtS Deacon
Aug 12, 1998·The American Journal of Psychiatry·O T DolbergL Grunhaus
Sep 16, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M L DubocovichM I Masana
Sep 15, 1999·Nature·K KräuchiA Wirz-Justice
Dec 23, 1999·The Journal of Endocrinology·S W LockleyJ Arendt
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K KräuchiA Wirz-Justice
Oct 12, 2000·The New England Journal of Medicine·R L SackA J Lewy
Dec 16, 2000·Trends in Biochemical Sciences·M W Young
Mar 10, 2001·Nature·J D ClaytonS M Reppert
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·I V ZhdanovaO U Leclair

❮ Previous
Next ❯

Citations

Nov 1, 2011·European Journal of Nutrition·Glyn HowatsonJason Ellis
Jan 23, 2013·BMC Complementary and Alternative Medicine·Cheng-long XieGuo-qing Zheng
May 28, 2010·Der Internist·S SchwarzM Deuschle
May 10, 2011·Expert Opinion on Investigational Drugs·D Alan Lankford
Oct 2, 2013·Chest·Jeremy A Weingarten, Nancy A Collop
Nov 19, 2011·Best Practice & Research. Clinical Rheumatology·Michael SpaethPiercarlo Sarzi-Puttini
Nov 24, 2011·Journal of Pineal Research·Sergio A Rosales-CorralRussel J Reiter
Mar 20, 2016·Current Psychiatry Reports·Emily BadinJess Parker Shatkin
Sep 16, 2011·Expert Opinion on Pharmacotherapy·Regina M Carney, Richard C Shelton
May 15, 2012·Expert Opinion on Pharmacotherapy·Octavian C Ioachimescu, Ali A El-Solh
Jan 13, 2015·Expert Opinion on Therapeutic Patents·Silvia RivaraGilberto Spadoni
Aug 28, 2014·Chinese Journal of Integrative Medicine·Yan-Li HuangGuo-Ping Zhao
Dec 3, 2013·Molecular and Cellular Endocrinology·Gaia FaveroRita Rezzani
Jun 4, 2013·Fertility and Sterility·John E Morley
Jan 5, 2011·International Journal of Alzheimer's Disease·Venkatramanujam SrinivasanDaniel P Cardinali
Jun 11, 2010·Expert Opinion on Therapeutic Patents·Marco MorGiorgio Tarzia
Apr 6, 2012·Journal of Biological Rhythms·Gang WangVincent M Cassone
Oct 22, 2013·The Medical Journal of Australia·Delwyn J BartlettStuart M Armstrong
Nov 28, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tahir MuhammadMyeong Ok Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zeitschrift für Gerontologie und Geriatrie
M G Olde Rikkert, A S Rigaud
The Psychiatric Clinics of North America
Denise Troy CurryJames K Walsh
Frontiers in Neuroendocrinology
M Mila Macchi, Jeffrey N Bruce
© 2021 Meta ULC. All rights reserved