Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

Journal of Nanobiotechnology
Yanglin WuJun Lin

Abstract

Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin had a therapeutic effect on wear-particles induced osteolysis. Gut microbiota is closely related to bone homeostasis, and has been proven to be affected by melatonin. However, whether melatonin could play its anti-osteolysis effects through reprogramming gut microbiota remains elusive. Here, we demonstrated that melatonin could alleviate Ti-particles induced osteolysis, while this therapeutic effect was blocked by antibiotic cocktail treatment. Interestingly, transplantation of fecal microbiota from mice treated with melatonin reappeared the same beneficial effect. Analysis of the 16S rRNA revealed that melatonin could reverse dysbacteriosis triggered by osteolysis, and elevate the relative abundance of some short chain fatty acid (SCFA) producing bacteria. Moreover, butyrate was enriched by exogenous melatonin administration, while acetate and propionate did not show an evident difference. This was consistent with the results of the metagenomic approach (PICRUSt2) analysis, which revealed a general increase in the synthe...Continue Reading

References

Dec 4, 2004·Clinical Orthopaedics and Related Research·William H Harris
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Nov 29, 2007·The ISME Journal·Cecilia JernbergJanet K Jansson
Dec 24, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marco S CaicedoNadim J Hallab
Mar 24, 2009·Annual Review of Immunology·Fabio MartinonJürg Tschopp
Dec 22, 2009·Nature Immunology·Rongbin ZhouJürg Tschopp
Aug 14, 2010·Microbiology·Cecilia JernbergJanet K Jansson
Sep 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Les Dethlefsen, David A Relman
Sep 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christine A St PierreRobert W Finberg
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Apr 4, 2012·Journal of AOAC International·George T Macfarlane, Sandra Macfarlane
Aug 31, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lyndsey BurtonP Edward Purdue
May 25, 2013·Nature Reviews. Immunology·Eicke LatzAndrea Stutz
Jun 25, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marco S CaicedoNadim J Hallab
Sep 24, 2013·Immunity·Haitao WenJenny P-Y Ting
Dec 25, 2013·Frontiers in Immunology·Rojo A RatsimandresyChristian Stehlik
May 27, 2014·Cell·Mohamed Lamkanfi, Vishva M Dixit
Jan 30, 2015·Journal of Pineal Research·Talita da Silva Mendes de FariasFabio Bessa Lima
Sep 12, 2015·The ISME Journal·Frédéric RaymondJacques Corbeil
Apr 26, 2016·The Journal of Clinical Investigation·Jau-Yi LiRoberto Pacifici
Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jing YanJulia F Charles
Feb 16, 2017·Journal of Pineal Research·Pengfei XuYonggong Zhai
May 16, 2017·Current Neuropharmacology·Sylvie TordjmanClaire Fougerou
Jun 2, 2017·The Journal of Clinical Investigation·Gabriel MbalavieleSteven L Teitelbaum
Jun 7, 2017·British Journal of Pharmacology·Rana Jahanban-EsfahlanAlireza Sadeghpour
Sep 7, 2017·Journal of Pineal Research·Wenkai RenYulong Yin
Sep 30, 2017·Gut Microbes·Jing YanJulia F Charles
Jan 6, 2018·Nature Communications·Sébastien LucasMario M Zaiss
Jan 11, 2018·Nature Communications·Dakota E McCoyRichard O Prum
Dec 21, 2018·The Journal of Investigative Dermatology·Lazaro Emilio AiraSandrine Marchetti
Jan 1, 2019·Journal of Pineal Research·Tian LiYang Yang
Apr 1, 2019·Journal of Pineal Research·Ting GaoYaoxing Chen
May 15, 2019·The Journal of Allergy and Clinical Immunology·Anna TheilerAkos Heinemann

❮ Previous
Next ❯

Software Mentioned

metacyc
Micro
PICRUSt2
CT
LEfSe
Sigmaplot

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.