Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of adult Wistar rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Samuel Gbadebo OlukoleBankole Olusiji Oke

Abstract

Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that has been demonstrated to induce alterations in reproductive organs while melatonin (ML), an antioxidant, present in plants and animals, is capable of protecting against EDC-induced alterations. Adult male Wistar rats (average weight, 240 + 10 g) were divided into four groups of ten animals each: Rats in group I (control) received oral 0.2 ml 1% dimethyl sulfoxide (DMSO)/99% canola oil as vehicle; group II received intra-peritoneal 10 mg/kg BW/day ML. Group III received oral BPA dissolved in DMSO and solubilized in canola oil at 10 mg/kg BW/day. Group IV were treated with same dose of BPA as group III with a concomitant intra-peritoneal 10 mg/kg BW/day ML. All treatments lasted for 14 days. BPA significantly increased the prostatic index of the rats while ML ameliorated it. BPA significantly increased serum levels of estrogen as well as prostate-specific antigen but decreased serum testosterone in the rats while concomitant treatment with ML ameliorated these alterations. Also, BPA caused vascular congestion, hyperplasia (functional, reactive and atypical) of prostatic epithelium as well as tubular atrophy the rats while ML attenuated the observed lesions. Decrease...Continue Reading

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Citations

Jul 30, 2020·Biomolecules·Shehreen AmjadMyung-Geol Pang
Jan 8, 2019·Environmental Science and Pollution Research International·Samuel Gbadebo OlukoleBankole Olusiji Oke
Dec 28, 2019·International Journal of Environmental Research and Public Health·Jong-Joo KimVijay Kumar
Aug 8, 2019·Environmental Science and Pollution Research International·Samuel Gbadebo OlukoleBankole Olusiji Oke
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Olufunke E Ola-Davies, Samuel G Olukole

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