Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer

Journal of Pineal Research
Francisco Javier PadilloJordi Muntané

Abstract

Pancreatic cancer is a major health problem because of the aggressiveness of the disease and the lack of effective systemic therapies. Melatonin (MEL) has antioxidant activity and prevents experimental genotoxicity. The specific inhibitor of cyclooxygenase-2 (COX-2), celecoxib (CEL), increases the efficacy of chemoradiotherapy in advanced pancreatic cancer. The objective of the study was the comparison and synergic effect of MEL and CEL during either the induction or progression phases of the tumor process, measuring parameters of oxidative stress, number of tumor nodules and survival of animals with pancreatic cancer. Pancreatic cancer was induced by N-nitrosobis (2-oxopropyl)amine) (BOP) in Syrian hamsters. Melatonin and/or CEL were administered during the induction, postinduction as well as during both phases. The presence of tumor nodules were observed macroscopically in pancreatic and splenic areas, and the levels of lipoperoxides (LPO), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in pancreatic tissue were measured. The increases in tumor nodules and LPO as well as the reductions in GSH and enzymatic antioxidants in the pancreas induced by BOP were related to a ...Continue Reading

References

May 1, 1977·Journal of the National Cancer Institute·P PourU Mohr
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Jan 1, 1984·Methods in Enzymology·H Aebi
Apr 21, 1998·Pancreas·S OkadaT Kakizoe
Apr 8, 1999·Journal of Clinical Pathology·J M Radhi, B E Lukie
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R A WoutersenA Van Garderen-Hoetmer
Feb 5, 2000·Carcinogenesis·M T Yip-SchneiderC J Sweeney
Mar 18, 2000·Advances in Experimental Medicine and Biology·C Bartsch, H Bartsch
Oct 26, 2001·Seminars in Radiation Oncology·H A JonesW G McKenna
Dec 1, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F A WengerJ M Müller
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Vladimir N AnisimovAnatoly I Yashin
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Fumio FurukawaMasao Hirose
Feb 28, 2003·Molecular Cancer·Sabine Westphal, Holger Kalthoff
Dec 17, 2003·Journal of Pineal Research·Carmen RodriguezRussel J Reiter
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Mar 31, 2004·Lancet·Donghui LiJames L Abbruzzese
Apr 7, 2004·Current Oncology Reports·Simona M PinoJames L Abbruzzese
Jun 12, 2004·Current Gastroenterology Reports·Simona M PinoJames L Abbruzzese
Sep 11, 2004·Journal of Pineal Research·Russel J Reiter
Oct 12, 2005·Endocrine·Antonio Carrillo-VicoRussel J Reiter
Jul 26, 2007·Journal of Digestive Diseases·You Shi LiuHen Jun Gao
Sep 7, 2007·Journal of Pineal Research·Juan F Ruiz-RabeloFrancisco Javier Padillo
Nov 15, 2007·Cancer Biology & Therapy·Hiroyuki MatsubayashiMichael Goggins
Feb 6, 2008·Cancer Chemotherapy and Pharmacology·Pieter de HeerPeter J K Kuppen
Feb 19, 2008·Current Opinion in Cardiology·John Gorcsan
Oct 25, 2008·Nature Reviews. Cancer·Christopher C Benz, Christina Yau
Apr 30, 2009·Molecular Microbiology·Alastair G McEwan
Jun 26, 2009·Journal of Pineal Research·Ignacio BejaranoAna B Rodríguez

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Citations

Apr 22, 2014·International Journal of Molecular Sciences·Sara SalucciElisabetta Falcieri
Sep 17, 2013·Expert Opinion on Therapeutic Targets·Mariano BizzarriRussel J Reiter
Aug 1, 2015·International Journal of Molecular Sciences·Aroha SánchezBeatriz Clares
Dec 19, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chunfang XuJiaqing Shen
Jan 28, 2014·Journal of Chemical Information and Modeling·Yongmei PanStephen H Bryant
Jul 15, 2011·Journal of Pineal Research·Virginia MotilvaMatilde Illanes
Jan 20, 2011·Journal of Pineal Research·Yu-Fang XiongHong-Xing Wang
May 12, 2012·Molecular and Cellular Endocrinology·Ana Coto-MontesRussel J Reiter
Apr 20, 2017·International Journal of Molecular Sciences·Russel J ReiterKexin Xu
Mar 27, 2013·International Journal of Molecular Sciences·Carmen RodriguezIsaac Antolín
Sep 20, 2018·Journal of Cellular Physiology·Omid Reza TamtajiZatollah Asemi
Feb 23, 2018·World Journal of Gastroenterology : WJG·Mercedes Rubio-Manzanares DoradoJavier Padillo Ruiz
Dec 20, 2018·International Journal of Molecular Sciences·Bianka BojkováKarol Kajo
Sep 3, 2020·European Journal of Pharmacology·Mohammad Hossein PourhanifehAzam Hosseinzadeh

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