Melatonin and Comorbidities in Children with Autism Spectrum Disorder

Current Developmental Disorders Reports
Katia Gagnon, Roger Godbout

Abstract

Melatonin is used to treat sleep difficulties associated with autism spectrum disorder (ASD). There are growing evidence that melatonin could have an effect on other symptoms than sleep, such as anxiety, depression, pain, and gastrointestinal dysfunctions. Interestingly, these symptoms frequently are found as comorbid conditions in individuals with ASD. We aimed to highlight the potential effect of melatonin on these symptoms. Animal and human studies show that melatonin reduces anxiety. Regarding the effect of melatonin on pain, animal studies are promising, but results remain heterogeneous in humans. Both animal and human studies have found that melatonin can have a positive effect on gastrointestinal dysfunction. Melatonin has the potential to act on a wide variety of symptoms associated with ASD. However, other than sleep difficulties, no studies exist on melatonin as a treatment for ASD comorbid conditions. Such investigations should be on the research agenda because melatonin could improve a multitude of ASD comorbidities and, consequently, improve well-being.

References

Mar 6, 1999·Developmental Medicine and Child Neurology·A L Richdale
May 5, 2000·Digestive Diseases and Sciences·M JarrettV Hertig
Oct 2, 2002·Digestive Diseases and Sciences·Filippo DragoSoudabeh Salehi
Oct 25, 2002·Digestive Diseases and Sciences·George A Bubenik
Jan 18, 2003·Sleep Medicine Reviews·Harvey Moldofsky
Oct 18, 2003·BMC Psychiatry·Pekka TaniTarja Porkka-Heiskanen
Jun 4, 2004·Developmental Medicine and Child Neurology·Luci Wiggs, Gregory Stores
Jan 18, 2005·Biological Psychiatry·Sylvie TordjmanYvan Touitou
Feb 12, 2005·Brain : a Journal of Neurology·Elyse LimogesRoger Godbout
Oct 12, 2005·Endocrine·Antonio Carrillo-VicoRussel J Reiter
May 23, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Grace T BaranekLinda R Watson
Aug 26, 2006·Sleep Medicine·Candice A AlfanoDaniel S Lewin
Mar 7, 2007·Journal of Autism and Developmental Disorders·E Juulia PaavonenEeva T Aronen
May 17, 2007·Molecular Psychiatry·J MelkeT Bourgeron
Oct 20, 2007·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Ayelet Ben-SassonWinnie Dunn
Jul 29, 2009·Current Psychiatry Reports·Thomas W UhdeAndrei Vedeniapin
Dec 17, 2009·Brain Research Bulletin·Venkataramanujam SrinivasanDaniel P Cardinali
Mar 23, 2009·International Journal of Tryptophan Research : IJTR·Dawn M RichardDonald M Dougherty
Dec 18, 2010·Expert Review of Clinical Immunology·Garth R SwansonAli Keshavarzian
May 17, 2011·Research in Developmental Disabilities·Jill A Hollway, Michael G Aman
May 24, 2011·Pediatric Clinics of North America·Ann M Reynolds, Beth A Malow
Jun 28, 2011·Research in Developmental Disabilities·Halina RzepeckaShona Murphy
Dec 4, 2012·Current Neuropharmacology·Venkatramanujam SrinivasanAmnon Brzezinski
Oct 1, 2013·Sleep Medicine Reviews·Florian ChouchouGilles J Lavigne
Feb 6, 2014·Autism : the International Journal of Research and Practice·Megan E TudorMatthew D Lerner
Mar 15, 2014·World Journal of Gastroenterology : WJG·Kewin Tien Ho SiahKhek Yu Ho
Apr 23, 2014·Journal of Autism and Developmental Disorders·Suzanne E GoldmanBeth A Malow
May 20, 2014·Anaesthesia·L P H AndersenI Gögenur
Dec 3, 2014·Physiology & Behavior·Aleksandra TomovaDaniela Ostatnikova
Jan 28, 2015·International Journal of Molecular Medicine·Young-Sook ParkHaing-Woon Baik
Mar 20, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Tushar Patel, Madhuri S Kurdi
May 8, 2015·Journal of Clinical Laboratory Analysis·Banafsheh Seyyed KhezriAnders Larsson
Jul 15, 2015·Biological Research for Nursing·Margaret M HeitkemperKevin C Cain
Feb 24, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Marta ZielińskaJakub Fichna
Mar 18, 2016·Pain and Therapy·Andrei Danilov, Julia Kurganova

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Citations

Dec 6, 2019·Current Pharmaceutical Design·Iliyana Pacheva, Ivan Ivanov
Sep 20, 2020·Journal of Autism and Developmental Disorders·Bárbara Virginia Vitti-RuelaMonica Levy Andersen
Mar 16, 2019·Journal of Translational Medicine·Susanna EspositoElisabetta Mencaroni
Aug 7, 2020·Continuum : Lifelong Learning in Neurology·Amy Licis
Mar 19, 2020·Brain Sciences·Rosa MarottaMichele Roccella
Feb 26, 2019·Frontiers in Endocrinology·Tal Shomrat, Nir Nesher
Jul 3, 2021·Journal of Personalized Medicine·Heather WayJordan Reeder
Jun 29, 2021·Journal of Autism and Developmental Disorders·Masaharu HayashiYushiro Yamashita

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Methods Mentioned

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