Melatonin and human chronobiology

Cold Spring Harbor Symposia on Quantitative Biology
A J Lewy

Abstract

With the development of accurate and sensitive assays for measuring melatonin in plasma and saliva, it has been possible to advance our understanding of human chronobiology. In particular, the dim light melatonin onset (DLMO) is expected to have an increasingly important role in the diagnosis of circadian phase disorders and their treatment with appropriately timed bright light exposure and/or low-dose melatonin administration. The phase angle difference (PAD) between DLMO and mid-sleep can be used as a marker for internal circadian alignment and may also be used to differentiate individuals who are phase advanced from those who are phase delayed (a long interval indicates the former and a short interval indicates the latter). To provide a corrective phase delay, light exposure should be scheduled in the evening and melatonin should be administered in the morning. To provide a corrective phase advance, light exposure should be scheduled in the morning and melatonin should be administered in the afternoon/evening. The study of patients with seasonal affective disorder (SAD), as well as individuals who are totally blind, has resulted in several findings of interest to basic scientists, as well as psychiatrists and sleep specialists.

References

Jun 1, 1979·Pediatric Research·S M ReppertD C Klein
Aug 1, 1976·Endocrinology·Y Ozaki, H J Lynch
Dec 1, 1975·International Journal of Biometeorology·H J LynchR J Wurtman
Oct 1, 1992·Chronobiology International·A J LewyR L Sack
Oct 1, 1992·Sleep·R L SackA J Lewy
May 11, 1991·Lancet·M DahlitzJ D Parkes
Nov 1, 1990·Trends in Neurosciences·V M Cassone
Jan 1, 1991·Journal of Biological Rhythms·R E Mistlberger
Jan 1, 1991·Journal of Biological Rhythms·R L SackL D Keith
Nov 1, 1990·Acta Psychiatrica Scandinavica·D H AveryD L Dunner
Jan 1, 1989·Chronobiology International·A J Lewy, R L Sack
Oct 7, 1988·Science·S M ReppertE G Stopa
Jan 1, 1986·Journal of Pineal Research·H Underwood
Jan 16, 1987·Science·A J LewyT M Hoban
Jun 1, 1985·The American Journal of Psychiatry·A J LewyD A Newsome
Feb 14, 1981·Lancet·A J LewyN E Rosenthal
Oct 24, 1981·Lancet·J A SmithA A Schiff
Oct 1, 1983·Psychiatry Research·D F KripkeD Janowsky
May 12, 1983·The New England Journal of Medicine·E A Neuwelt, A J Lewy
Jan 1, 1983·Pflügers Archiv : European journal of physiology·R A WeverC M Wildgruber
Jun 1, 1983·The Journal of Clinical Endocrinology and Metabolism·A J Lewy, D A Newsome
Nov 1, 1982·The American Journal of Psychiatry·A J LewyT A Wehr
Jan 1, 1980·The Journal of Clinical Endocrinology and Metabolism·A J LewyI J Kopin
Dec 12, 1980·Science·A J LewyS P Markey
Jan 5, 1995·The New England Journal of Medicine·C A CzeislerJ F Rizzo
Dec 1, 1993·Archives of General Psychiatry·A Wirz-JusticeW Pöldinger
Nov 5, 1997·Journal of Biological Rhythms·A VoultsiosD Dawson
Nov 5, 1997·Journal of Biological Rhythms·B MiddletonB M Stone
Dec 24, 1997·Journal of Biological Rhythms·J ArendtS Deacon
Dec 24, 1997·Journal of Biological Rhythms·C A Czeisler
Mar 7, 1998·European Journal of Biochemistry·M Sonnier, T Cresteil

❮ Previous
Next ❯

Citations

Dec 27, 2011·Age·Henryk F Urbanski, Krystina G Sorwell
Nov 17, 2009·Current Psychiatry Reports·Alfred J Lewy
Jul 3, 2013·Psychiatry Research·Kathryn RoeckleinPeter Franzen
May 26, 2012·TheScientificWorldJournal·Rüdiger Hardeland
Jul 9, 2009·Computational Intelligence and Neuroscience·Milka CulicBjörn Wahlund
Jun 4, 2014·International Review of Psychiatry·Kelly Glazer Baron, Kathryn J Reid
Oct 15, 2013·Expert Review of Neurotherapeutics·J J Sandra Kooij, Denise Bijlenga
Apr 23, 2010·Expert Opinion on Investigational Drugs·Rüdiger Hardeland
Jul 22, 2014·Expert Opinion on Drug Metabolism & Toxicology·Sara ProiettiMariano Bizzarri
May 20, 2015·European Child & Adolescent Psychiatry·Stephanie GestTanja Legenbauer
Jul 17, 2009·Pharmacological Reports : PR·Jolanta B ZawilskaJosephine Arendt
Jan 1, 2013·Biological Psychiatry·Andrew N CooganJohannes Thome
Dec 22, 2011·Mutation Research. Reviews in Mutation Research·Russel J ReiterDun-Xian Tan
Jan 18, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aya SenooMamiko Koshiba
Dec 5, 2008·Lancet·Daniel P Cardinali, Diego A Golombek
Feb 25, 2009·Travel Medicine and Infectious Disease·Gregory M BrownDaniel P Cardinali
Aug 29, 2014·Journal of Pineal Research·Vanesa MartínCarmen Rodriguez
Dec 25, 2009·American Journal of Medical Genetics. Part a·Constance L ChikAnn C M Smith
Nov 26, 2015·The Psychiatric Clinics of North America·Michael D Schwartz, Thomas S Kilduff
Jun 24, 2015·Journal of Pineal Research·Karolina Szewczyk-GolecRussel J Reiter
Mar 19, 2015·Journal of Psychiatric Research·W Vaughn McCall
Jan 29, 2014·Medical Hypotheses·Stephanie GestMartin Holtmann
Oct 12, 2014·Neuroscience Research·Mamiko KoshibaHironobu Tokuno
Jan 5, 2013·Neuroscience and Biobehavioral Reviews·Kathryn A RoeckleinGeorge C Brainard
Jun 24, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ritsuko MatsumuraMakoto Akashi
Sep 30, 2010·Journal of Biological Rhythms·Jonathan EmensJeannie B Songer
Jul 27, 2018·Psychiatry Investigation·Hyera RyuSooyeon Suh
Jul 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Alfred Lewy
Mar 7, 2020·Cells·Enrico MorettiRita Rezzani
Jan 9, 2017·Attention Deficit and Hyperactivity Disorders·Andrew N Coogan, Niall M McGowan
Mar 31, 2019·Attention Deficit and Hyperactivity Disorders·Denise BijlengaMartijn Arns
Sep 28, 2018·Journal of Behavioral Medicine·Deepika GoyalKathryn Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved