Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial

Physiology & Behavior
Valdir de Aquino LemosMarco Tulio De Mello

Abstract

This work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation period for all groups was approximately 36 h, beginning with a first night devoid of any intervention. Aerobic exercise was performed by the EN and EH groups on a treadmill at 50% of the ventilatory threshold intensity for 60 min. Sleep evaluation was performed on the 1st and 2nd nights. Venous blood samples for the melatonin measurement were obtained on the 1st and 2nd days at 7:30 AM as well as on the 1st and 2nd nights at 10:30 PM. On the 2nd night, melatonin was higher in the H group than in the N group, but both were lower than values of the EH group. The nocturnal increase in melatonin was inversely correlated with the oxygen saturation of hemoglobin (SaO2%) on the 2nd night in the H group and on the 2nd day in the EH group. Diurnal remission of nocturnal melatonin appeared to be postponed in the H group and even more so in the EH group. Thus, normobaric hypoxia, which is equivalent to oxygen availability at an a...Continue Reading

References

Mar 1, 1990·Journal of Applied Physiology·R J ConnettG A Brooks
Jan 1, 1989·Journal of Pineal Research·G S SkrinarJ W McArthur
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·D B CarrJ W McArthur
Jan 1, 1995·Canadian Journal of Physiology and Pharmacology·C Saiki, J P Mortola
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·A N EliasN James
Feb 5, 2000·Journal of Applied Physiology·J P Mortola, E L Seifert
Jun 14, 2001·Respiration Physiology·M VargasJ P Mortola
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T MiyazakiK I Honma
Jan 15, 2003·Experimental Physiology·Hans HoppelerMartin Flück
Oct 17, 2003·High Altitude Medicine & Biology·Gerardo BoscoJacopo P Mortola
Jul 3, 2004·Journal of Pineal Research·Olivier CosteYvan Touitou
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Herwig FrischKatharina Schweitzer
Aug 16, 2005·Journal of Pineal Research·Russel J ReiterMaria D Maldonado
Aug 30, 2008·Brain Research·K Gonca AkbulutHakan Akbulut
May 15, 2009·Biology of Reproduction·Russel J ReiterRosa M Sainz
Jul 25, 2009·Journal of Pineal Research·C VenerosoPilar S Collado
Jun 11, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francesca LuchettiFrancesco Galli
Oct 6, 2010·High Altitude Medicine & Biology·P HimadriS Dhananjay
Aug 19, 2011·Journal of Pineal Research·Germaine EscamesDario Acuña-Castroviejo
Apr 13, 2012·Science Translational Medicine·Orfeu M BuxtonSteven A Shea
Jun 5, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jacob Richards, Michelle L Gumz
Aug 17, 2012·Medicine and Science in Sports and Exercise·Raphael FaissGrégoire P Millet
Jan 29, 2013·Carcinogenesis·Raffaela SantoroSabrina Strano
May 29, 2013·Journal of Pineal Research·Caroline MendesJosé Cipolla-Neto
Jul 9, 2013·Biochemical and Biophysical Research Communications·Katsuhiro YoshiiIkuko Sagami
Sep 3, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Matthew D MullerChester A Ray
Jun 15, 2014·The Journal of Endocrinology·Shannon M BaileyMartin E Young
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Hayan LeeDonghee Kim
Feb 24, 2015·Biological Research for Nursing·Mariana G FigueiroBarbara Plitnick
Apr 17, 2015·Endocrine-related Cancer·Steven M HillDavid E Blask
Apr 25, 2015·Neuro-Chirurgie·B Claustrat, J Leston
Aug 12, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Pasquale F InnominatoGeorg A Bjarnason
Nov 10, 2015·Current Biology : CB·Robert H EckelKenneth P Wright
Dec 6, 2016·International Neurourology Journal·Dong Sup HwangOh Young Kwon

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Citations

Apr 14, 2020·Journal of Pineal Research·David J Kennaway
Jan 30, 2020·Cells·Alessandra StacchiottiLuigi Fabrizio Rodella
Feb 16, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Marisa PedemonteMonica L Andersen
Sep 3, 2021·The Journal of Physiological Sciences : JPS·Joanna KrukEwa Duchnik

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