Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

Future Medicinal Chemistry
Eva RamosAlejandro Romero

Abstract

Melatonin is an indoleamine produced mainly in the pineal gland. The natural decline of melatonin levels with aging strongly contributes to the development of neurodegenerative disorders. Pleiotropic actions displayed by melatonin prevent several processes involved in neurodegeneration such as neuroinflammation, oxidative stress, excitotoxicity and/or apoptosis. This review focuses on a number of melatonin hybrids resulting from the juxtaposition of tacrine, berberine, tamoxifen, curcumin, N,N-dibenzyl(N-methyl)amine, among others, with potential therapeutic effects for the treatment of neurodegenerative diseases.

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Citations

May 16, 2017·Future Medicinal Chemistry·Maria Laura Bolognesi
Mar 14, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Eva MezeiovaJan Korabecny
Feb 19, 2019·Journal of Drug Targeting·Badar Ul IslamShams Tabrez
Sep 21, 2019·Mini Reviews in Medicinal Chemistry·Yaghoub PourshojaeiAli Asadipour
Mar 17, 2019·International Journal of Molecular Sciences·Natalia Piekuś-SłomkaStanisław Sobiak
Sep 20, 2019·Neural Regeneration Research·Alejandro RomeroEva Ramos
Jun 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosa PurgatorioMarco Catto
Apr 10, 2019·Current Alzheimer Research·Eunice D Farfán-GarcíaMarvin A Soriano-Ursúa
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Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Chieh-Hsin LinHsien-Yuan Lane

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Methods Mentioned

BETA
three hybrids
acetylation
five hybrid

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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