Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation

International Journal of Endocrinology
Gaia FaveroRita Rezzani

Abstract

Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions. Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory cytokines. Melatonin, an endogenous indoleamine, is considered an important multitasking molecule with fundamental clinical applications. It is involved in mood modulation, sexual behavior, vasomotor control, and immunomodulation and influences energy metabolism; moreover, it acts as an oncostatic and antiaging molecule. Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions. This review, first, gives an overview concerning th...Continue Reading

References

Apr 1, 1979·Journal of Neurochemistry·M A RogawskiG K Aghajanian
Jan 1, 1990·Acta paediatrica Scandinavica·J K Lloyd
Jan 1, 1993·Life Sciences·G Benítez-KingF Antón-Tay
May 1, 1993·In Vitro Cellular & Developmental Biology. Animal·H S YuC G Wong
Aug 15, 1993·Experientia·R J Reiter
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Jan 16, 1997·The New England Journal of Medicine·A Brzezinski
Nov 27, 1999·Mechanisms of Ageing and Development·R J ReiterV Rouvier-Garay
Jun 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S CuzzocreaD Salvemini
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MartínD Acuña-Castroviejo
Mar 28, 2001·Annals of the New York Academy of Sciences·R J ReiterD X Tan
Mar 28, 2001·Annals of the New York Academy of Sciences·C Carlberg
Apr 25, 2001·European Journal of Clinical Pharmacology·G FaccioláG Tybring
Aug 30, 2001·European Journal of Pharmacology·S Cuzzocrea, R J Reiter
Mar 20, 2002·Current Topics in Medicinal Chemistry·Salvatore Cuzzocrea, Russel J Reiter
Feb 21, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonio Carrillo-VicoJuan M Guerrero
Feb 27, 2003·European Journal of Biochemistry·Manuel MacíasDarío Acuña-Castroviejo
Mar 12, 2003·Life Sciences·Paula A Witt-EnderbyMelissa A Melan
Mar 29, 2003·Journal of Pineal Research·Rüdiger Hardeland, Burkhard Poeggeler
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Margarita L DubocovichMonica I Masana
Jul 15, 1960·Biochimica Et Biophysica Acta·A WEISSBACH
Nov 25, 2004·The Journal of Clinical Endocrinology and Metabolism·Antonio Carrillo-VicoJuan M Guerrero
Dec 8, 2004·Experimental Gerontology·M Karasek
Jan 15, 2005·Sleep Medicine Reviews·Bruno ClaustratGuy Chazot
Sep 27, 2005·Experimental Gerontology·S R Pandi-PerumalD P Cardinali
Oct 12, 2005·Endocrine·Margarita L Dubocovich, Magdalena Markowska
Oct 29, 2005·Biochemical Pharmacology·Fanny VellaJean A Boutin
Mar 11, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C Ekmekcioglu
Jul 5, 2006·The FEBS Journal·S R Pandi-PerumalR Hardeland
Jul 25, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Venkataramanujan SrinivasanDaniel P Cardinali
Sep 2, 2006·The Journal of Pharmacy and Pharmacology·Germaine EscamesRussel J Reiter
Dec 14, 2006·Free Radical Research·María I RodríguezDarío Acuña-Castroviejo
Mar 14, 2007·Journal of Pineal Research·María I RodríguezDarío Acuña-Castroviejo
Mar 21, 2007·The FEBS Journal·Germaine EscamesDarío Acuña-Castroviejo

❮ Previous
Next ❯

Citations

Jun 20, 2018·Annals of the New York Academy of Sciences·Kanchan VatsPallab Bhattacharya
Sep 23, 2018·Journal of Pineal Research·Rüdiger Hardeland
Oct 15, 2018·Journal of Cellular Physiology·Bagher FarhoodAmirhossein Sahebkar
Dec 27, 2018·Journal of Pineal Research·María Elisa MercauCora Beatriz Cymeryng
Mar 15, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ramy K A SayedDarío Acuña-Castroviejo
Feb 14, 2019·Annals of the New York Academy of Sciences·Mayuri ShuklaRussel J Reiter
Aug 4, 2018·Current Molecular Pharmacology·Peyman AminiMasoud Najafi
Jul 18, 2019·International Journal of Molecular Sciences·Francesca BonominiRita Rezzani
Oct 2, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Ryul KimBeomseok Jeon
Nov 6, 2018·BMC Immunology·Dean HuggardEleanor J Molloy
Nov 9, 2019·Behavioural Pharmacology·Lais S RodriguesMarcelo M S Lima
Sep 25, 2019·Medicina·Tassiane C MoraisLuiz C de Abreu
Jan 12, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Luqman OlayakiJulius Omoniyi
Feb 23, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Adetayo Sadudeen AmidFadeyemi Joseph Akinrinmade
Jun 20, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiang LiHui Liu
Jul 1, 2020·Journal of Pineal Research·Somanathapura K NaveenKumarKesturu S Girish
Feb 19, 2019·Journal of Alzheimer's Disease : JAD·Tobore Onojighofia Tobore
Feb 13, 2020·International Journal of Molecular Sciences·Hiroshi TamuraNorihiro Sugino
Aug 23, 2020·International Journal of Molecular Sciences·Jarosław NuszkiewiczKarolina Szewczyk-Golec
Aug 24, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B FarhoodM Najafi
Sep 12, 2018·International Journal of Molecular Sciences·Tong-Hong WangChi-Yuan Chen
Apr 15, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Tobore Onojighofia Tobore
May 2, 2018·Current Medicinal Chemistry·Geir BjorklundSalvatore Chirumbolo
Feb 14, 2019·Oxidative Medicine and Cellular Longevity·Xu WuLei Zhu
Nov 6, 2018·Frontiers in Pharmacology·Gaia FaveroRita Rezzani
Apr 26, 2020·International Journal of Molecular Sciences·Lorenzo NardoMiguel Pampaloni
May 11, 2018·Current Hypertension Reports·Natalia Jorgelina PradoEmiliano Raúl Diez
Jan 15, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javier MarhuendaPilar Zafrilla
Oct 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafael GenarioHeitor O Santos
Jan 16, 2021·International Journal of Molecular Sciences·Kenneth K Wu
Nov 11, 2020·Antioxidants·Nadia FerlazzoDaniela Caccamo
Mar 4, 2021·Cancers·Caritha KlassonLinda Björkhem-Bergman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

© 2022 Meta ULC. All rights reserved