Melatonin attenuates arsenic induced nephropathy via the regulation of oxidative stress and inflammatory signaling cascades in mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Sayanta DuttaParames C Sil

Abstract

Arsenic is a potent inducer of several acute and chronic nephrotoxic disorders. It promotes deleterious phenomenon like oxidative stress, inflammation, cell death and altered glucose uptake leading to distorted kidney homeostasis that end up in chronic kidney disease. This study investigated the possible protective role of melatonin; a natural antioxidant produced by the pineal gland, against arsenic induced nephrotoxicity. Melatonin successfully ameliorated arsenic induced renal toxicity both in in vitro and in vivo models. Elevated BUN, creatinine, urine glucose and protein levels and altered renal histopathological conditions were observed in arsenic intoxicated mice. Significant oxidative stress induced damage of biomolecules along with downregulation in antioxidant enzymes and thiols were also detected in the kidney tissues of arsenic-intoxicated mice. These alterations along with mitochondrial dysfunction ultimately triggered TNFα mediated inflammatory and cell death cascades. Interestingly arsenic also led to disruption of glucose uptake in the kidney. These findings suggest that melatonin protects the kidney against toxic effect of arsenic, presumably through its antioxidant, anti-inflammatory and antidiabetic propertie...Continue Reading

Citations

Jul 31, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zeynep Banu DoğanlarOğuzhan Doğanlar
Jan 10, 2020·Environmental Science and Pollution Research International·Mehmet Erman ErdemliHarika Gozukara Bag
May 26, 2020·BioFactors·Sasivimon Promsan, Anusorn Lungkaphin
Aug 17, 2018·International Journal of Molecular Sciences·Minghui YangGuoshi Liu
Jan 28, 2021·Human & Experimental Toxicology·Anna SkoczynskaMarek Scieszka
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May 19, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohammed Al Za'abiBadreldin H Ali
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