Melatonin attenuates methamphetamine-induced inhibition of proliferation of adult rat hippocampal progenitor cells in vitro

Journal of Pineal Research
K EkthuwapraneeP Govitrapong

Abstract

Methamphetamine (METH) is an extremely addictive stimulatory drug. A recent study suggested that METH may cause an impairment in the proliferation of hippocampal neural progenitor cells, but the underlying mechanism of this effect remains unknown. Blood and cerebrospinal levels of melatonin derive primarily from the pineal gland, and that performs many biological functions. Our previous study demonstrated that melatonin promotes the proliferation of progenitor cells originating from the hippocampus. In this study, hippocampal progenitor cells from adult Wistar rats were used to determine the effects of METH on cell proliferation and the mechanisms underlying these effects. We investigated the effects of melatonin on the METH-induced alteration in cell proliferation. The results demonstrated that 500 μm METH induced a decrease (63.0%) in neurosphere cell proliferation and altered the expression of neuronal phenotype markers in the neurosphere cell population. Moreover, METH induced an increase in the protein expression of the tumor suppressor p53 (124.4%) and the cell cycle inhibitor p21(CIP) (1) (p21) (128.1%), resulting in the accumulation of p21 in the nucleus. We also found that METH altered the expression of the N-methyl-d-...Continue Reading

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Citations

Oct 16, 2015·Cellular and Molecular Life Sciences : CMLS·Chi XuPing-Yee Law
Aug 9, 2016·Journal of Pineal Research·Russel J ReiterLilian Qin
May 14, 2017·Journal of Pineal Research·Tania Galván-ArrietaGloria Benítez-King
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Aug 13, 2020·International Journal of Molecular Sciences·Joseph Wai-Hin LeungBenson Wui-Man Lau
Nov 2, 2019·Behavioural Brain Research·Sakineh Alizadeh GolsorkhdanMohammad Javad Fridoni

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