Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression

Reproduction : the Official Journal of the Society for the Study of Fertility
Qingling YangYingpu Sun

Abstract

The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration as a result of the aging process. Melatonin is considered to be an anti-aging agent. However, the underlying mechanisms of how melatonin improves the quality of postovulatory aged oocytes remain largely unclear. In this study, by using mouse model, we found that there were elevated reactive oxygen species levels and impaired mitochondrial function demonstrated by reduced mitochondrial membrane potential and increased mitochondrial aggregation in oocytes aged 24 h, accompanied by an increased number of meiotic errors, unregulated autophagy-related proteins and early apoptosis, which led to decreased oocyte quality and disrupted developmental competence. However, all of these events can be largely prevented by supplementing the oocyte culture medium with 10-3 M melatonin. Additionally, we found that the expression of sirtuin family members (SIRT1, 2 and 3) was dramatically reduced in aged oocytes. In addition, in vitro supplementation with melatonin significantly upregulated the expression of SIRT1 and antioxidant enzyme MnSOD, but this action was not observed for SIRT2 and SIRT3. Furthermore, the protective effect of melatonin on the delay...Continue Reading

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Citations

Dec 13, 2018·Human Reproduction Update·Jacinta H MartinBrett Nixon
Jan 17, 2020·Molecular Human Reproduction·Pengfei ZhangWenxian Zeng
May 19, 2020·Journal of Pineal Research·Hyocheol BaeWhasun Lim
Jan 2, 2020·Antioxidants & Redox Signaling·Alexandra E PetersJessie M Sutherland
Jul 31, 2019·Reproductive Biology and Endocrinology : RB&E·Qingling YangYingpu Sun
Dec 1, 2020·Frontiers in Cell and Developmental Biology·Yuan LiuLing Gu
Nov 13, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jimei XiaoZhengao Sun
Jan 23, 2021·Free Radical Biology & Medicine·Feifei ZhaoYing-Pu Sun
Aug 19, 2021·Animal Science Journal = Nihon Chikusan Gakkaihō·Mei-Ju LiuXue-Yuan Heng

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