PMID: 7580870Aug 1, 1995Paper

Melatonin biosynthesis in photoreceptor-enriched chick retinal cell cultures: role of cyclic AMP in the K(+)-evoked, Ca(2+)-dependent induction of serotonin N-acetyltransferase activity

Neurochemistry International
J GanP M Iuvone

Abstract

The roles of cyclic AMP and calcium in the regulation of serotonin N-acetyltransferase (NAT) activity were studied in low density monolayer cultures of chick retinal photoreceptors and neurons. Photoreceptor-enriched retinal cell cultures were prepared from embryonic day 6 retinas and cultured for 6 days. NAT activity in these cultures could be induced by treatment with cyclic AMP protagonists, 8Br-cyclic AMP, forskolin, and 3-isobutyl-1-methylxanthine (IBMX), or by treatment with depolarizing concentrations of extracellular K+. The stimulatory effect of K+, which involves Ca2+ influx through dihydropyridine-sensitive channels, was mediated at least in part by cyclic AMP, as indicated by the following observations. Depolarizing concentrations of K+ stimulated the formation of cyclic AMP, and the stimulatory effects of K+ on both cyclic AMP formation and on NAT activity were synergistically potentiated by the cyclic nucleotide phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). MDL 12,330A, a putative adenylate cyclase inhibitor, inhibited K(+)-evoked cyclic AMP accumulation and induction of NAT activity over the identical concentration range. In contrast, MDL 12,300A failed to inhibit the induction of NAT elicited b...Continue Reading

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Citations

Feb 3, 2007·Visual Neuroscience·Per O LundmarkDaniel P Cardinali
Mar 5, 2008·Progress in Retinal and Eye Research·Allan F Wiechmann, Jody A Summers
Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·Mustafa AkhisarogluTolga Uz
Apr 23, 2005·Progress in Retinal and Eye Research·P Michael IuvoneShyam S Chaurasia
Sep 24, 2004·Neurochemistry International·John W Wellard, Ian G Morgan
May 25, 2004·Journal of Biological Rhythms·Minoru Hasegawa, Gregory M Cahill
May 25, 2010·Journal of Pineal Research·Ruth E RosensteinDaniel P Cardinali
Jan 15, 2011·Chronobiology International·Leonardo Henrique Ribeiro Graciani de LimaAna Maria de Lauro Castrucci

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