Melatonin blocks dexamethasone-induced immunosuppression in a seasonally breeding rodent Indian palm squirrel, Funambulus pennanti

Steroids
C HaldarRajesh Singh

Abstract

In vivo effect of dexamethasone and melatonin on immunomodulation has been investigated by studying the lymphocyte proliferation to the mitogen Con A from various lymphoid tissues including bone marrow cells of a seasonally breeding rodent adult male F. pennanti during reproductively inactive phase (October to December). During this phase, animal faces the maximum challenges of the nature (hypothermic stress, scarcity of food and shelter). Dexamethasone treatment (60 microg/day/squirrel) for 60 consecutive days significantly decreased the thymus and spleen activity. The lymphoid tissues mass, total leukocyte, lymphocyte count of peripheral blood, bone marrow and T-cell mediated immune function was also significantly suppressed following the dexamethasone treatment but treatment of melatonin (25 microg/squirrel/day) along with dexamethasone significantly restored the suppressed immune status in squirrels. Further, histological study of the thymus showed profound changes in the cellularity with a depletion of thymocytes in the cortex region of thymic lobules and increased in connective tissues and spindle cells. Melatonin treatment alone increased thymocytes density in thymic cortex, clearly suggesting that melatonin counteracted...Continue Reading

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Citations

Apr 29, 2014·Bulletin of Experimental Biology and Medicine·L S KalinichenkoE V Koplik
Jan 5, 2014·Inflammation·Katharina Effenberger-NeidnichtHerbert de Groot
Jan 3, 2007·Journal of Pineal Research·M D MaldonadoR J Reiter
Apr 24, 2013·International Journal of Molecular Sciences·Antonio Carrillo-VicoJuan M Guerrero
Jun 6, 2020·Archives of Physiology and Biochemistry·Sangita SutradharShiv Shankar Singh
Nov 13, 2018·Pakistan Journal of Biological Sciences : PJBS·Muddasir BasheerYounis Ahmad Hajam
Jul 9, 2020·Animals : an Open Access Journal From MDPI·Tanja HofmannVolker Stefanski

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